ArticleProceedings of the National Academy of Sciences of the United States of America2011
Transcriptome transfer provides a model for understanding the phenotype of cardiomyocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
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- Review Insights In Cardiac Tissue Engineering: Cells, Scaffolds, and Pharmacological Agents.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration.Developmental cell · 2020Article
- Dynamic Model for Characterizing Contractile Behaviors and Mechanical Properties of a Cardiomyocyte.Biophysical journal · 2018Article
- Challenges and emerging directions in single-cell analysis.Genome biology · 2017Review
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- Cardiac melanocytes influence atrial reactive oxygen species involved with electrical and structural remodeling in mice.Physiological reports · 2015Article
- Identifying functional gene regulatory network phenotypes underlying single cell transcriptional variability.Progress in biophysics and molecular biology · 2015Article
- Pluripotent state induction in mouse embryonic fibroblast using mRNAs of reprogramming factors.International journal of molecular sciences · 2014Article
- Combined biophysical and soluble factor modulation induces cardiomyocyte differentiation from human muscle derived stem cells.Scientific reports · 2014Article
- Inputs drive cell phenotype variability.Genome research · 2014Article
- Concise review: reprogramming strategies for cardiovascular regenerative medicine: from induced pluripotent stem cells to direct reprogramming.Stem cells translational medicine · 2014Review
- Determinants of expression variability.Nucleic acids research · 2014Article
- Engineered Human Muscle Tissue from Skeletal Muscle Derived Stem Cells and Induced Pluripotent Stem Cell Derived Cardiac Cells.International journal of tissue engineering · 2013Article
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- Induced regeneration--the progress and promise of direct reprogramming for heart repair.Nature medicine · 2013Review
- Reading and writing omes.Molecular systems biology · 2013Article
- Perspectives on cell reprogramming with RNA.Trends in biotechnology · 2012Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We show that the transfer of the adult ventricular myocyte (AVM) transcriptome into either a fibroblast or an astrocyte converts the host cell into a cardiomyocyte. Transcriptome-effected cardiomyocytes (tCardiomyocytes) display morphologies, immunocytochemical properties, and expression profiles of postnatal cardiomyocytes. Cell morphology analysis shows that tCardiomyoctes are elongated and have a similar length-to-width ratio as AVMs. These global phenotypic changes occur in a time-dependent manner and confer electroexcitability to the tCardiomyocytes. tCardiomyocyte generation does not require continuous overexpression of specific transcription factors; for example, the expression level of transcription factor Mef2c is higher in tCardiomyocytes than in fibroblasts, but similar in tCardiomyocytes and AVMs. These data highlight the dominant role of the gene expression profile in developing and maintaining cellular phenotype. The transcriptome-induced phenotype remodeling-generated tCardiomyocyte has significant implications for understanding and modulating cardiac disease development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.