ArticleInternational journal for parasitology2011
Vital functions of the malarial ookinete protein, CTRP, reside in the A domains.
Article in International journal for parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.PLoS pathogens · 2012Trial
- Advances in the dissection of Anopheles-Plasmodium interactions.PLoS pathogens · 2025Review
- Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission.Nature communications · 2022Article
- Evolutionary Insights into the Microneme-Secreted, Chitinase-Containing High-Molecular-Weight Protein Complexes Involved inInfection and immunity · 2022Article
- Thrombospondin Related Anonymous Protein Superfamily in Vector-Borne Apicomplexans: The Parasite's Toolkit for Cell Invasion.Frontiers in cellular and infection microbiology · 2022Review
- Article
- Evolutionarily distant I domains can functionally replace the essential ligand-binding domain ofeLife · 2020Article
- Malaria.tools-comparative genomic and transcriptomic database for Plasmodium species.Nucleic acids research · 2020Article
- A Hetero-Multimeric Chitinase-ContainingFrontiers in cellular and infection microbiology · 2020Article
- Immune Responses to the Sexual Stages ofFrontiers in immunology · 2019Review
- Ookinete-Specific Genes and 18S SSU rRNA Evidenced inFrontiers in genetics · 2019Article
- Functional characterization of Plasmodium berghei PSOP25 during ookinete development and as a malaria transmission-blocking vaccine candidate.Parasites & vectors · 2017Article
- The cell biology of malaria infection of mosquito: advances and opportunities.Cellular microbiology · 2015Review
- Host cell invasion by apicomplexan parasites: the junction conundrum.PLoS pathogens · 2014Review
- Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility.Cellular microbiology · 2014Article
- A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut.PLoS pathogens · 2013Article
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7 authors.
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Abstract
The transformation of malaria ookinetes into oocysts occurs in the mosquito midgut and is a major bottleneck for parasite transmission. The secreted ookinete surface protein, circumsporozoite- and thrombospondin-related adhesive protein (TRAP)-related protein (CTRP), is essential for this transition and hence constitutes a potential target for malaria transmission blockade. CTRP is a modular multidomain protein containing six tandem von Willebrand factor A-like (A) domains and seven tandem thrombospondin type I repeat-like (TS) domains. Here we present, to our knowledge, the first structure-function analysis of CTRP using genetically modified Plasmodium berghei parasites expressing mutant versions of the ctrp gene. Our data show that the A domains of CTRP are critical for ookinete gliding motility and oocyst formation whilst, unexpectedly, its TS domains are fully redundant. These results may have important implications for the design of CTRP-based transmission blocking strategies.
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