SynthesisParasitology2011
Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis.
Synthesis in Parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Epidemiological, clinical and immunological features of Schistosoma spp., Stronglyoides stercoralis and Taenia spp. infections in Ghanaian HIV patients.European journal of microbiology & immunology · 2025Article
- Schistosomiasis and HIV-1 viral load in HIV-infected outpatients with immunological failure in Tanzania: a case-control study.BMC infectious diseases · 2019Article
- Impact of schistosome infection on long-term HIV/AIDS outcomes.PLoS neglected tropical diseases · 2018Article
- HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected WithFrontiers in immunology · 2018Article
- Tropical Parasitic Infections in Individuals Infected with HIV.Current tropical medicine reports · 2017Article
- Hookworm infection is associated with decreased CD4+ T cell counts in HIV-infected adult Ugandans.PLoS neglected tropical diseases · 2017Article
- Prevalence and clinical relevance of helminth co-infections among tuberculosis patients in urban Tanzania.PLoS neglected tropical diseases · 2017Article
- Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk.AIDS research and human retroviruses · 2016Article
- Intestinal helminth infections amongst HIV-infected adults in Mthatha General Hospital, South Africa.African journal of primary health care & family medicine · 2015Article
- Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon.PLoS neglected tropical diseases · 2015Article
- Treatment of W. bancrofti (Wb) in HIV/Wb coinfections in South India.PLoS neglected tropical diseases · 2015Article
- Schistosoma haematobium infection and CD4+ T-cell levels: a cross-sectional study of young South African women.PloS one · 2015Article
- Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens.BMC microbiology · 2014Article
- Effect of helminth-induced immunity on infections with microbial pathogens.Nature immunology · 2013Review
- Triple worm infestation in an HIV-infected patient.Infection · 2013Article
- Epidemiology and interactions of Human Immunodeficiency Virus - 1 and Schistosoma mansoni in sub-Saharan Africa.Infectious diseases of poverty · 2013Article
- Helminthic infections rates and malaria in HIV-infected pregnant women on anti-retroviral therapy in Rwanda.PLoS neglected tropical diseases · 2013Article
- Helminth infection in populations undergoing epidemiological transition: a friend or foe?Seminars in immunopathology · 2012Review
- The effects of schistosomiasis on HIV/AIDS infection, progression and transmission.Current opinion in HIV and AIDS · 2012Review
- Integration of deworming into HIV care and treatment: a neglected opportunity.PLoS neglected tropical diseases · 2012Article
Corrections and comments
- Erratum issuedHerrin, Bradely R [corrected to Herrin, Bradley R]
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In sub-Saharan Africa, over 22 million people are estimated to be co-infected with both helminths and HIV-1. Several studies have suggested that de-worming individuals with HIV-1 may delay HIV-1 disease progression, and that the benefit of de-worming may vary by individual helminth species. We conducted a systematic review and meta-analysis of the published literature to determine the effect of treatment of individual helminth infections on markers of HIV-1 progression (CD4 count and HIV viral load). There was a trend towards an association between treatment for Schistosoma mansoni and a decrease in HIV viral load (Weighted mean difference (WMD)=-0·10; 95% Confidence interval (CI): -0·24, 0·03), although this association was not seen for Ascaris lumbricoides, hookworm or Trichuris trichiura. Treatment of A. lumbricoides, S. mansoni, hookworm or T. trichiura was not associated with a change in CD4 count. While pooled data from randomized trials suggested clinical benefit of de-worming for individual helminth species, these effects decreased when observational data were included in the pooled analysis. While further trials are needed to confirm the role of anthelmintic treatment in HIV-1 co-infected individuals, providing anthelmintics to individuals with HIV-1 may be a safe, inexpensive and practical intervention to slow progression of HIV-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.