ArticleBMC microbiology2011
Phenotypic and genotypic characterization of Stenotrophomonas maltophilia isolates from patients with cystic fibrosis: genome diversity, biofilm formation, and virulence.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed.
- Molecular Regulation of Biofilm Development inPathogens (Basel, Switzerland) · 2026Review
- Phenotypic and genomic insights into Stenotrophomonas sepilia SMBL8: metabolic versatility, antibiotic resistance and pathogenic potential.World journal of microbiology & biotechnology · 2026Article
- Enhanced Biofilm Formation by ICU-AssociatedMicroorganisms · 2026Article
- A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filaments.PLoS pathogens · 2026Article
- From nature to clinic: tracking genetic and environmental drivers of Stenotrophomonas maltophilia pathogenicity.Archives of microbiology · 2026Review
- A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filaments.bioRxiv : the preprint server for biology · 2026Article
- Antibiotic Resistance, Biofilm Genes, and smeDEF Efflux Pump in Clinical Stenotrophomonas maltophilia Isolates From Iran.MicrobiologyOpen · 2026Article
- Therapeutic Potential of a NovelInternational journal of molecular sciences · 2026Article
- Genomic characterization of a mobile-element-associated resistance island in trimethoprim-sulfamethoxazole-resistantFrontiers in cellular and infection microbiology · 2026Article
- Investigation of virulence factors and genes associated with biofilm and protease inIranian journal of microbiology · 2025Article
- Ceftazidime retainsmSphere · 2025Article
- First Report ofAntibiotics (Basel, Switzerland) · 2025Article
- The COVID-19 pandemic: an underlying factor for increasedFrontiers in microbiology · 2025Review
- Persistence ofMicroorganisms · 2024Article
- Review
- Evaluation of ethanol and EDTA concentrations in the expression of biofilm-producing smf-1, rpfF genes in XDR clinical isolates of Stenotrophomonas maltophilia.BMC microbiology · 2023Article
- Improved mini-TnApplied and environmental microbiology · 2023Article
- Efficacy in Galleria mellonella Larvae and Application Potential Assessment of a New Bacteriophage BUCT700 Extensively Lyse Stenotrophomonas maltophilia.Microbiology spectrum · 2023Article
- A guide toFrontiers in cellular and infection microbiology · 2023Review
- Comparative genomics analysis ofFrontiers in cellular and infection microbiology · 2023Article
12 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
backgroundStenotrophomonas maltophilia is emerging as one of the most frequently found bacteria in cystic fibrosis (CF) patients. In the present study, phenotypic and genotypic traits of a set of 98 isolates of S. maltophilia obtained from clinical (CF and non-CF patients) and environmental sources were comparatively evaluated.
resultsS. maltophilia exhibited a high level of genomic diversity in both CF and non-CF group, thus possibly allowing this bacterium to expand its pathogenic potentials. Strains sharing the same pulsotype infected different patients, thus likely indicating the occurrence of clonal spread or acquisition by a common source. CF isolates differed greatly in some phenotypic traits among each other and also when compared with non-CF isolates, demonstrating increased mean generation time and susceptibility to oxidative stress, but reduced ability in forming biofilm. Furthermore, in CF isolates flagella- and type IV pili-based motilities were critical for biofilm development, although not required for its initiation. Sequential isogenic strains isolated from the same CF patient displayed heterogeneity in biofilm and other phenotypic traits during the course of chronic infection. CF and non-CF isolates showed comparable virulence in a mouse model of lung infection.
conclusionsOverall, the phenotypic differences observed between CF and non-CF isolates may imply different selective conditions and persistence (adaptation) mechanisms in a hostile and heterogeneous environment such as CF lung. Molecular elucidation of these mechanisms will be essential to better understand the selective adaptation in CF airways in order to design improved strategies useful to counteract and eradicate S. maltophilia infection.
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