Evidence map›Paper›PMID 21729235›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2011

Dose-response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)-a systematic review and meta-analyses.

J Patra, R Bakker, H Irving, V W V Jaddoe, S Malini, J Rehm

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 25 pooled it
37.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

218 citing papers in PubMed, 25 syntheses or guidelines pooled it, 555 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. Pooled it

158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

J PatraCentre for Addiction and Mental Health, Toronto, ON, Canada. jayadeep_patra@camh.net
R Bakker
H Irving
V W V Jaddoe
S Malini
J Rehm
Centre for Addiction and Mental Health · CAErasmus University Rotterdam · NLKlinik und Poliklinik für Psychotherapie und Psychosomatik · DEMaharaja Krishna Chandra Gajapati Medical College and Hospital · IN

Funding

NIAAA NIH HHS HHSN267200700041CNIDDK NIH HHS HHSN267200700041C
6 · The paper itself

Abstract

backgroundDescriptions of the effects of moderate alcohol consumption during pregnancy on adverse pregnancy outcomes have been inconsistent.

objectiveTo review systematically and perform meta-analyses on the effect of maternal alcohol exposure on the risk of low birthweight, preterm birth and small for gestational age (SGA). SEARCH STRATEGY: Using Medical Subject Headings, a literature search of MEDLINE, EMBASE, CINAHL, CABS, WHOlist, SIGLE, ETOH, and Web of Science between 1 January 1980 and 1 August 2009 was performed followed by manual searches. SELECTION CRITERIA: Case-control or cohort studies were assessed for quality (STROBE), 36 available studies were included. DATA COLLECTION AND ANALYSIS: Two reviewers independently extracted the information on low birthweight, preterm birth and SGA using a standardised protocol. Meta-analyses on dose-response relationships were performed using linear as well as first-order and second-order fractional polynomial regressions to estimate best fitting curves to the data. MAIN

resultsCompared with abstainers, the overall dose-response relationships for low birthweight and SGA showed no effect up to 10 g pure alcohol/day (an average of about 1 drink/day) and preterm birth showed no effect up to 18 g pure alcohol/day (an average of 1.5 drinks/day); thereafter, the relationship showed a monotonically increasing risk for increasing maternal alcohol consumption. Moderate consumption during pre-pregnancy was associated with reduced risks for all outcomes.

conclusionsDose-response relationship indicates that heavy alcohol consumption during pregnancy increases the risks of all three outcomes whereas light to moderate alcohol consumption shows no effect. Preventive measures during antenatal consultations should be initiated.

Indexed as

Infant, Low Birth WeightInfant, Small for Gestational AgeAlcohol DrinkingDose-Response Relationship, DrugFemaleHumansInfant, NewbornPregnancyPremature BirthRegression AnalysisRiskRisk Factors

Identifiers

PMID21729235
PMCPMC3394156
OpenAlexW2150870806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.