Evidence map›Paper›PMID 21728976›Full record

ReviewCurrent pharmaceutical design2011

Novel neuropeptides as ligands of orphan G protein-coupled receptors.

Yan Zhang, Zhiwei Wang, Gregory Scott Parks, Olivier Civelli

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current pharmaceutical design, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yan ZhangDepartment of Pharmacology, University of California Irvine, Irvine, CA 92697, United States.
Zhiwei Wang
Gregory Scott Parks
Olivier Civelli
University of California, Irvine · US

Funding

CHARACTERIZATION OF TWO NOVEL NEUROPEPTIDESR01MH060231 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI CIVELLI, OLIVIER · 1999 to 2008
$2.7M
A novel neuropeptide system involved in drug abuseR01DA024746 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CIVELLI, OLIVIER · 2010 to 2013
$1.5M
NIDA NIH HHS DA024746NIDA NIH HHS R01 DA024746NIMH NIH HHS MH60231NIMH NIH HHS R01 MH060231
6 · The paper itself

Abstract

Neuropeptides control a wide spectrum of physiological functions. They are central to our understanding of brain functions. They exert their actions by interacting with specific G protein-coupled receptors. We however have not found all the neuropeptides that exist in organisms. The search for novel neuropeptides is thus of great interest as it will lead to a better understanding of brain function and disorders. In this review, we will discuss the historical as well as the current approaches to neuropeptide discovery, with a particular emphasis on the orphan GPCR-based strategies. We will also discuss two novel peptides, neuropeptide S and neuromedin S, as examples of the impact of neuropeptide discovery on our understanding of brain functions. Finally, the challenges facing neuropeptide discovery will be discussed.

Indexed as

AnimalsBrainBrain DiseasesHumansLigandsNeuropeptidesReceptors, G-Protein-CoupledLigandsneuromedin SNeuropeptidesneuropeptide S, humanReceptors, G-Protein-Coupled

Identifiers

PMID21728976
PMCPMC5828022
OpenAlexW2041358763

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.