ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2011
Formation of morphogen gradients: local accumulation time.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Morphogen gradients are regulated by porous media characteristics of the developing tissue.Development (Cambridge, England) · 2025Article
- Cellular diffusion processes in singularly perturbed domains.Journal of mathematical biology · 2024Review
- Article
- Stationary CaBiophysical journal · 2021Article
- Article
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction.PLoS computational biology · 2018Article
- The organelle of differentiation in embryos: the cell state splitter.Theoretical biology & medical modelling · 2016Review
- On the GFP-based analysis of dynamic concentration profiles.Biophysical journal · 2014Article
- Kinetics of receptor occupancy during morphogen gradient formation.The Journal of chemical physics · 2013Article
- Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway.Molecular biology of the cell · 2012Article
- Transient exposure to TGF-β3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels.Journal of the mechanical behavior of biomedical materials · 2012Article
- Physical interpretation of mean local accumulation time of morphogen gradient formation.The Journal of chemical physics · 2011Article
- Ordinary differential equation for local accumulation time.The Journal of chemical physics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Spatial regulation of cell differentiation in embryos can be provided by morphogen gradients, which are defined as the concentration fields of molecules that control gene expression. For example, a cell can use its surface receptors to measure the local concentration of an extracellular ligand and convert this information into a corresponding change in its transcriptional state. We characterize the time needed to establish a steady-state gradient in problems with diffusion and degradation of locally produced chemical signals. A relaxation function is introduced to describe how the morphogen concentration profile approaches its steady state. This function is used to obtain a local accumulation time that provides a time scale that characterizes relaxation to steady state at an arbitrary position within the patterned field. To illustrate the approach we derive local accumulation times for a number of commonly used models of morphogen gradient formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.