ArticleJournal of proteome research2011
The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
Article in Journal of proteome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 81 citations in OpenAlex.
- The Case for Vinegar Ingestion.Nutrients · 2026Review
- Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes.Cell biology international · 2025Article
- Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology.Frontiers in physiology · 2025Review
- Quantifying Protein Acetylation in Diabetic Nephropathy from Formalin-Fixed Paraffin-Embedded Tissue.Proteomics. Clinical applications · 2024Article
- Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges.Nature reviews. Cardiology · 2023Review
- Chronic exercise remodels the lysine acetylome in the mouse hippocampus.Frontiers in molecular neuroscience · 2022Article
- A comprehensive mouse brain acetylome-the cellular-specific distribution of acetylated brain proteins.Frontiers in cellular neuroscience · 2022Article
- VDACs Post-Translational Modifications Discovery by Mass Spectrometry: Impact on Their Hub Function.International journal of molecular sciences · 2021Review
- Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet.Analytical biochemistry · 2021Article
- Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.Circulation research · 2020Article
- Regulation of metabolism by mitochondrial enzyme acetylation in cardiac ischemia-reperfusion injury.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions.Journal of proteome research · 2020Article
- Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis-Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases.Frontiers in physiology · 2020Review
- Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.Molecular cell · 2018Article
- Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle.International journal of molecular sciences · 2018Review
- Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest.PloS one · 2018Article
- Article
- Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.Cell reports · 2017Article
- Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals.Oxidative medicine and cellular longevity · 2017Review
- Normalization of NAD+ Redox Balance as a Therapy for Heart Failure.Circulation · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The elucidation of extra-nuclear lysine acetylation has been of growing interest, as the cosubstrate for acetylation, acetyl CoA, is at a key metabolic intersection. Our hypothesis was that mitochondrial and cytoplasmic protein acetylation may be part of a fasted/re-fed feedback control system for the regulation of the metabolic network in fuel switching, where acetyl CoA would be provided by fatty acid oxidation, or glycolysis, respectively. To test this, we characterized the mitochondrial and cytoplasmic acetylome in various organs that have a high metabolic rate relative to their mass, and/or switch fuels, under fasted and re-fed conditions (brain, kidney, liver, skeletal muscle, heart muscle, white and brown adipose tissues). Using immunoprecipitation, coupled with LC-MS/MS label free quantification, we show there is a dramatic variation in global quantitative profiles of acetylated proteins from different organs. In total, 733 acetylated peptides from 337 proteins were identified and quantified, out of which 31 acetylated peptides from the metabolic proteins that may play organ-specific roles were analyzed in detail. Results suggest that fasted/re-fed acetylation changes coordinated by organ-specific (de)acetylases in insulin-sensitive versus -insensitive organs may underlie fuel use and switching. Characterization of the tissue-specific acetylome should increase understanding of metabolic conditions wherein normal fuel switching is disrupted, such as in Type II diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.