ArticleAnalytical chemistry2011
Carbon nanotube microwell array for sensitive electrochemiluminescent detection of cancer biomarker proteins.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 218 citations in OpenAlex.
- The Synthesis of Ru-Co-Oxalate MOFs for an Electrochemiluminescent Glyphosate Sensor.Biosensors · 2026Article
- Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoSSensors (Basel, Switzerland) · 2024Article
- Tris(2,2'-bipyridyl)ruthenium (II) complex as a universal reagent for the fabrication of heterogeneous electrochemiluminescence platforms and its recent analytical applications.Analytical and bioanalytical chemistry · 2023Review
- Recent Progress and Challenges on the Microfluidic Assay of Pathogenic Bacteria Using Biosensor Technology.Biomimetics (Basel, Switzerland) · 2022Review
- Nanomaterial-assisted microfluidics for multiplex assays.Mikrochimica acta · 2022Review
- Multiplexed Prostate Cancer Companion Diagnostic Devices.Sensors (Basel, Switzerland) · 2021Review
- Electrochemical Biosensors for Cytokine Profiling: Recent Advancements and Possibilities in the Near Future.Biosensors · 2021Review
- Carbon Nanotube Field-Effect Transistor-Based Chemical and Biological Sensors.Sensors (Basel, Switzerland) · 2021Review
- Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis.Frontiers in oncology · 2021Review
- Impedimetric Detection of Femtomolar Levels of Interleukin6, Interleukin 8, and Tumor Necrosis Factor Alpha Based on Thermally Modified Nanotubular Titanium Dioxide Arrays.Nanomaterials (Basel, Switzerland) · 2020Article
- One-tube smart genetic testing via coupling isothermal amplification and three-way nucleic acid circuit to glucometers.Analytica chimica acta · 2020Article
- A Comparison of Commercially Available Screen-Printed Electrodes for Electrogenerated Chemiluminescence Applications.Frontiers in chemistry · 2020Article
- Detection of anti-p53 autoantibodies in saliva using microfluidic chips for the rapid screening of oral cancer.RSC advances · 2018Article
- Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9.Scientific reports · 2017Article
- Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review.Molecules (Basel, Switzerland) · 2017Review
- Nanomaterials for Electrochemical Immunosensing.Sensors (Basel, Switzerland) · 2017Review
- An Overview of Carbon Nanotubes and Graphene for Biosensing Applications.Nano-micro letters · 2017Review
- Biomolecular engineering for nanobio/bionanotechnology.Nano convergence · 2017Review
- Microalgae in Microwell Arrays Exhibit Differences with Those in Flasks: Evidence from Growth Rate, Cellular Carotenoid, and Oxygen Production.Frontiers in plant science · 2017Article
- Multiplex Immunosensor Arrays for Electrochemical Detection of Cancer Biomarker Proteins.Electroanalysis · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
This paper describes fabrication of a novel electrochemiluminescence (ECL) immunosensor array featuring capture-antibody-decorated single-wall carbon nanotube (SWCNT) forests residing in the bottoms of 10-μL wells with hydrophobic polymer walls. Silica nanoparticles containing [Ru(bpy)(3)](2+) and secondary antibodies (RuBPY-silica-Ab(2)) are employed in this system for highly sensitive two-analyte detection. Antibodies to prostate specific antigen (PSA) and interleukin-6 (IL-6) were attached to the same RuBPY-silica-Ab(2) particle. The array was fabricated by forming the wells on a conductive pyrolytic graphite chip (1 in. × 1 in.) with a single connection to a potentiostat to achieve ECL. The sandwich immunoassay protocol employs antibodies attached to SWCNTs in the wells to capture analyte proteins. Then RuBPY-silica-Ab(2) is added to bind to the captured proteins. ECL is initiated in the microwells by electrochemical oxidation of tripropyl amine (TprA), which generates excited state [Ru(bpy)(3)](2+) in the 100-nm particles, and is measured with a charge-coupled device (CCD) camera. Separation of the analytical spots by the hydrophobic wall barriers enabled simultaneous immunoassays for two proteins in a single sample without cross-contamination. The detection limit (DL) for PSA was 1 pg mL(-1) and for IL-6 was 0.25 pg mL(-1) (IL-6) in serum. Array determinations of PSA and IL-6 in patient serum were well-correlated with single-protein ELISAs. These microwell SWCNT immunoarrays provide a simple, sensitive approach to the detection of two or more proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.