ArticleAnalytical chemistry2011
Single-monomer formulation of polymerized polyethylene glycol diacrylate as a nonadsorptive material for microfluidics.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
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- Auto-amplification and spatial propagation of neutrophil extracellular traps.Communications biology · 2024Article
- Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications.Lab on a chip · 2023Review
- Review
- Evaluating polymeric biomaterials to improve next generation wound dressing design.Biomaterials research · 2022Review
- Rapid and simple pressure-sensitive adhesive microdevice fabrication for sequence-specific capture and fluorescence detection of sepsis-related bacterial plasmid gene sequences.Analytical and bioanalytical chemistry · 2021Article
- Microfabricated Devices for Confocal Microscopy on Biological Samples.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Study on Functionality and Surface Modification of a Stair-Step Liquid-Triggered Valve for On-Chip Flow Control.Micromachines · 2020Article
- Biocompatible PEGDA Resin for 3D Printing.ACS applied bio materials · 2020Article
- A Non-Cytotoxic Resin for Micro-Stereolithography for Cell Cultures of HUVECs.Micromachines · 2020Article
- Digital Manufacturing for Microfluidics.Annual review of biomedical engineering · 2019Review
- High-Precision Stereolithography of Biomicrofluidic Devices.Advanced materials technologies · 2019Article
- 3D Printed Microfluidic Probes.Scientific reports · 2018Article
- Characterization of 3D-Printed Moulds for Soft Lithography of Millifluidic Devices.Micromachines · 2018Article
- Custom 3D printer and resin for 18 μm × 20 μm microfluidic flow channels.Lab on a chip · 2017Article
- Isolated Reporter Bacteria in Supramolecular Hydrogel Microwell Arrays.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Moving from millifluidic to truly microfluidic sub-100-μm cross-section 3D printed devices.Analytical and bioanalytical chemistry · 2017Article
- Integrated electrokinetically driven microfluidic devices with pH-mediated solid-phase extraction coupled to microchip electrophoresis for preterm birth biomarkers.Electrophoresis · 2017Article
- High density 3D printed microfluidic valves, pumps, and multiplexers.Lab on a chip · 2016Article
- Optical Approach to Resin Formulation for 3D Printed Microfluidics.RSC advances · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nonspecific adsorption in microfluidic systems can deplete target molecules in solution and prevent analytes, especially those at low concentrations, from reaching the detector. Polydimethylsiloxane (PDMS) is a widely used material for microfluidics, but it is prone to nonspecific adsorption, necessitating complex chemical modification processes to address this issue. An alternative material to PDMS that does not require subsequent chemical modification is presented here. Poly(ethylene glycol) diacrylate (PEGDA) mixed with photoinitiator forms on exposure to ultraviolet (UV) radiation a polymer with inherent resistance to nonspecific adsorption. Optimization of the polymerized PEGDA (poly-PEGDA) formula imbues this material with some of the same properties, including optical clarity, water stability, and low background fluorescence, that make PDMS so popular. Poly-PEGDA demonstrates less nonspecific adsorption than PDMS over a range of concentrations of flowing fluorescently tagged bovine serum albumin solutions, and poly-PEGDA has greater resistance to permeation by small hydrophobic molecules than PDMS. Poly-PEGDA also exhibits long-term (hour scale) resistance to nonspecific adsorption compared to PDMS when exposed to a low (1 μg/mL) concentration of a model adsorptive protein. Electrophoretic separations of amino acids and proteins resulted in symmetrical peaks and theoretical plate counts as high as 4 × 10(5)/m. Poly-PEGDA, which displays resistance to nonspecific adsorption, could have broad use in small volume analysis and biomedical research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.