ArticleProstate cancer and prostatic diseases2011
Predictive value of digital rectal examination for prostate cancer detection is modified by obesity.
Article in Prostate cancer and prostatic diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Is there a role for body mass index in the assessment of prostate cancer risk on biopsy?The Journal of urology · 2014Trial
- Performance ofMolecular imaging and radionuclide therapy · 2025Article
- Obesity and prostate cancer screening, incidence, and mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.Journal of the National Cancer Institute · 2023Article
- Are associations between obesity and prostate cancer outcomes following radical prostatectomy the same in smokers and non-smokers? Results from the SEARCH Cohort.Cancer causes & control : CCC · 2023Article
- Selective Bone Scan staging for patients with Prostate cancer: do absolute categories really make sense?Prostate cancer and prostatic diseases · 2022Article
- Impact of Body Mass Index on the Accuracy of Physical Examination and MRI of the Shoulder.Orthopaedic journal of sports medicine · 2021Article
- Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference.BMC cancer · 2020Article
- Obesity and prostate cancer-specific mortality after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.Prostate cancer and prostatic diseases · 2017Article
- Does obesity modify prostate cancer detection in a European cohort?Central European journal of urology · 2017Article
- Correlation between body mass index (BMI) and the Gleason score of prostate biopsies in Chinese population.Oncotarget · 2016Article
- Obesity and cancer: mechanistic insights from transdisciplinary studies.Endocrine-related cancer · 2015Review
- Metabolic syndrome and prostate cancer risk in a population-based case-control study in Montreal, Canada.BMC public health · 2015Article
- The effects of serum from prostate cancer patients with elevated body mass index on prostate cancer cells in vitro.Lipid insights · 2015Article
- Left lobe of the prostate during clinical prostate cancer screening: the dark side of the gland for right-handed examiners.Prostate cancer and prostatic diseases · 2014Article
- Ethnicity is an independent determinant of age-specific PSA level: findings from a multiethnic Asian setting.PloS one · 2014Article
- Obesity and prostate cancer: weighing the evidence.European urology · 2013Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
The American Cancer Society's updated screening guidelines for prostate cancer (CaP) render digital rectal examination (DRE) optional. We investigated the impact of DRE on CaP detection among obese men. Data from 2794 men undergoing initial prostate biopsy at three centers were analyzed to assess CaP risk attributed to abnormal DRE across body mass index (BMI) categories. Predictive accuracies of a combination of PSA, age, race, center and biopsy year including or excluding DRE findings were compared by areas under the receiver-operating characteristics curves. In all cohorts, obese men were less likely to have abnormal DREs diagnosed than non-obese men. As BMI category increased, abnormal DREs became stronger predictors for overall CaP in individual (P-trends ≤ 0.05) and combined (P-trend<0.001) cohorts, and for high-grade CaP in the Italian (P-trend=0.03) and combined (P-trend=0.03) cohorts. DRE inclusion improved the predictive accuracy for overall and high-grade CaP detection among all obese men (P ≤ 0.032) but not normal-weight men (P ≥ 0.198). DRE inclusion also near-significantly improved overall CaP detection in obese men with PSA<4 ng ml(-1) (P=0.081). In conclusion, the predictive value of DRE is dependent on obesity and is significantly higher among obese men than normal-weight men.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.