Evidence map›Paper›PMID 21727733›Full record

ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Antibiotic susceptibility profile of Helicobacter pylori isolated from the dyspepsia patients in Tehran, Iran.

Leila Shokrzadeh, Fereshteh Jafari, Hossein Dabiri, Kaveh Baghaei, Homayoun Zojaji, Amir H Alizadeh, Mohammad Mehdi Aslani, Mohammad R Zali

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. The efficacy and safety of furazolidone-bismuth quadruple therapy forGastroenterology and hepatology from bed to bench · 2022
    Article
  5. Article
  6. High Prevalence of Antibiotic Resistance in IranianJournal of clinical medicine · 2019
    Article
  7. Article
  8. Eradication ofMiddle East journal of digestive diseases · 2018
    Review
  9. Review
  10. Evaluation of antimicrobial susceptibility and integron carriage inGastroenterology and hepatology from bed to bench · 2016
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Helicobacter pylori eradication in West Asia: a review.World journal of gastroenterology · 2014
    Review
  18. Review
  19. Resistance pattern of Helicobacter pylori strains to clarithromycin, metronidazole, and amoxicillin in Isfahan, Iran.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leila ShokrzadehResearch Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fereshteh Jafari
Hossein Dabiri
Kaveh Baghaei
Homayoun Zojaji
Amir H Alizadeh
Mohammad Mehdi Aslani
Mohammad R Zali

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimHelicobacter pylori is an important pathogen for gastroduodenal diseases. Infection with H. pylori can be limited by regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. The aim of this study has been to determine the resistance patterns of H. pylori strains isolated from gastric biopsies of patients with dyspepsia by agar dilution method, in Tehran, Iran. PATIENTS AND

methodsH. pylori isolates from patients with gastrointestinal diseases were evaluated for susceptibility testing by agar dilution method. Susceptibility testing was performed to commonly used antibiotics including clarithromycin, tetracycline, amoxicillin, metronidazole and ciprofloxacin.

resultsAmong 92 patients with dyspepsia, H. pylori strains were isolated from 42 patients. Seventeen (40.5%) of the isolates were resistant to metronidazole (MICs ≥ 8 μg/l), whereas one isolate (2.4%) was resistant to amoxicillin (MICs ≤ 0. 5 μg/ml) and ciprofloxacin (MICs ≤ 1μg/ml). The resistance rates to other antibiotics in H. pylori isolates are recorded as follows: clarithromycin 6 (14.3 %), tetracycline 2 (4.8%). In 5 of 42 resistant cases, combined resistance was found.

conclusionsThese data suggest that metronidazole should be used among Iranian patients in first-line therapy with caution, and ciprofloxacin in association with amoxicillin and a proton pump inhibitor is more recommended.

Indexed as

Drug Resistance, Multiple, BacterialAdultAnti-Bacterial AgentsBiopsy, NeedleCiprofloxacinCohort StudiesDyspepsiaFemaleGastroscopyHelicobacter InfectionsHelicobacter pyloriHumansImmunohistochemistryIranMaleMetronidazoleAnti-Bacterial AgentsCiprofloxacinMetronidazoleTetracycline

Identifiers

PMID21727733
PMCPMC3133984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.