ArticleIndian journal of public health
Risk factors associated with MDR-TB at the onset of therapy among new cases registered with the RNTCP in Mumbai, India.
Article in Indian journal of public health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Whole-genome sequencing of clinical isolates from tuberculosis patients in India: real-world data indicates a high proportion of pre-XDR cases.Microbiology spectrum · 2024Article
- Tuberculosis Pathways to Care and Transmission of Multidrug Resistance in India.American journal of respiratory and critical care medicine · 2022Article
- Predictors of Multidrug-Resistant Tuberculosis (MDR-TB) in Sudan.Antibiotics (Basel, Switzerland) · 2019Article
- Possible impact of the standardized Category IV regimen on multidrug-resistant tuberculosis patients in Mumbai.Lung India : official organ of Indian Chest SocietyArticle
- Drug-resistant tuberculosis: Response to MoreJournal of family medicine and primary careArticle
- Epidemiological profile of multidrug-resistant tuberculosis patients in Gorakhpur Division, Uttar Pradesh, India.Journal of family medicine and primary careArticle
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5 authors.
Funding
Abstract
backgroundMultidrug - resistant TB (MDR - TB) has emerged as a major threat to global TB control efforts in recent years. Facilities for its diagnosis and treatment are limited in many high - burden countries, including India. In hyper - endemic areas like Mumbai, screening for newly diagnosed cases at a higher risk of acquiring MDR - TB is necessary, for initiating appropriate and timely treatment, to prevent its further spread.
objectiveTo assess risk factors associated with MDR - TB among Category I, new sputum smear-positive cases, at the onset of therapy. MATERIALS AND
methodsThe study applied an unmatched case - control design for 514 patients (106 cases with MDR - TB strains and 408 controls with non - MDR - TB strains). The patients were registered with the Revised National Tuberculosis Control Program (RNTCP) in four selected wards of Mumbai during April 2004 - January 2007. Data were collected through semi - structured interviews and drug susceptibility test results.
resultsMultivariate analysis indicated that infection with the Beijing strain (OR = 3.06; 95% C.I. = 1.12 - 8.38; P = 0.029) and female gender (OR = 1.68; 95% C.I. = 1.02 - 2.87; P = 0.042) were significant predictors of MDR-TB at the onset of therapy.
conclusionThe study provides a starting point to further examine the usefulness of these risk factors as screening tools in identifying individuals with MDR-TB, in settings where diagnostic and treatment facilities for MDR-TB are limited.
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