Trial reportThe British journal of psychiatry : the journal of mental science2011
Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder.
Trial report in The British journal of psychiatry : the journal of mental science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00105586 (Pharmacotherapy of Late-Life Generalized Anxiety Disorder), which is not on this map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacotherapy of Late-Life Generalized Anxiety Disorder
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- The Relationship Between Cognitive Functioning and Symptoms of Depression, Anxiety, and Post-Traumatic Stress Disorder in Adults with a Traumatic Brain Injury: a Meta-Analysis.Neuropsychology review · 2022Pooled it
- The effects of selective serotonin reuptake inhibitors on memory functioning in older adults: A systematic literature review.Journal of psychopharmacology (Oxford, England) · 2022Pooled it
- Anxiety symptoms bias memory assessment in older adults.International journal of geriatric psychiatry · 2017Trial
- Cognitive-behavioral therapy augmentation of SSRI reduces cortisol levels in older adults with generalized anxiety disorder: A randomized clinical trial.Journal of consulting and clinical psychology · 2016Trial
- Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone.International journal of geriatric psychiatry · 2014Trial
- Escitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2A and 1B receptors.The international journal of neuropsychopharmacology · 2013Trial
- Treatment-related alteration of cortisol predicts change in neuropsychological function during acute treatment of late-life anxiety disorder.International journal of geriatric psychiatry · 2012Trial
- Memory in Psychiatric Disorders: A Review.Life (Basel, Switzerland) · 2025Review
- Profiling Generalized Anxiety Disorder on Social Networks: Content and Behavior Analysis.Journal of medical Internet research · 2025Article
- Hypoactivity of the Prefrontal Cortex During Go/No-Go Task in Patients With Generalized Anxiety Disorder.Depression and anxiety · 2025Article
- Neurocognitive disparities: investigating ethnicity and mental health in rural aging adults.Aging · 2024Article
- Anxiety in late-life depression is associated with poorer performance across multiple cognitive domains.Journal of the International Neuropsychological Society : JINS · 2024Article
- Hippocampal subfield volume in older adults with and without mild cognitive impairment: Effects of worry and cognitive reappraisal.Neurobiology of aging · 2024Article
- How emotional contexts modulate item memory in individuals with high and low negative affect and worry.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- White Noise-Is Anxiety in Late-Life Associated With White Matter Hyperintensity Burden?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Exploring the predictors of foreign language anxiety: the roles of language proficiency, language exposure, and cognitive control.Frontiers in psychiatry · 2024Article
- The association between satisfaction with life and anxiety symptoms among Chinese elderly: a moderated mediation analysis.BMC geriatrics · 2023Article
- Neuropsychology of Generalized Anxiety Disorder in Clinical Setting: A Systematic Evaluation.Healthcare (Basel, Switzerland) · 2023Review
- It goes both ways: The relationship between anxiety and mild cognitive impairment.International journal of geriatric psychiatry · 2023Article
- Effectiveness of vortioxetine in patients with major depressive disorder and co-morbid generalized anxiety disorder in routine clinical practice: A subgroup analysis of the RELIEVE study.Journal of psychopharmacology (Oxford, England) · 2023Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundGeneralised anxiety disorder (GAD) in older adults is associated with neuropsychological impairment. Aims We examined neuropsychological functioning in older adults with GAD in comparison with psychiatrically healthy older adults at baseline, and we examined changes following a 12-week placebo-controlled trial of escitalopram.
methodA total of 160 participants without dementia aged ≥60 with current GAD and 37 individuals in a comparison group without psychiatric history underwent neuropsychological assessment. Of these, 129 participants with GAD were reassessed post-treatment (trial registration: NCT00105586).
resultsThe participants with GAD performed worse than the comparison group in information processing speed, working memory, inhibition, problem-solving (including concept formation and mental flexibility) and immediate and delayed memory. Neuropsychological functioning was correlated with everyday functioning. After treatment, those with low cognitive scores experienced working memory, delayed memory and visuospatial ability improvement and those who reported clinical improvement in anxiety exhibited improvement in the ability to engage inhibition and episodic recall. These improvements were modest and of similar magnitude in both treatment conditions.
conclusionsGeneralised anxiety disorder in older adults is associated with neuropsychological impairments, which are associated with functional impairment. Those with GAD who either have a low cognitive performance or report clinical improvement in anxiety post-treatment, show improvement in multiple cognitive domains. These findings underscore the importance of treatments that aid cognition as well as anxiety symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.