ArticleThe Journal of physiology2011
Intracellular energy status regulates activity in hypocretin/orexin neurones: a link between energy and behavioural states.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025Review
- Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle.iScience · 2023Article
- LINE-1 activation in the cerebellum drives ataxia.Neuron · 2022Article
- AgRP neurons control structure and function of the medial prefrontal cortex.Molecular psychiatry · 2022Article
- From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective.Endocrine reviews · 2022Review
- The steroid hormone estriol (EBMC biology · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Orexin, serotonin, and energy balance.WIREs mechanisms of disease · 2022Review
- Synchronous neuronal interactions in rat hypothalamic culture: a novel model for the study of network dynamics in metabolic disorders.Experimental brain research · 2021Article
- Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states.Communications biology · 2020Article
- Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice.The Journal of clinical investigation · 2020Article
- The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats.Journal of neuroscience research · 2020Article
- DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.Cell metabolism · 2017Article
- UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.Cell · 2016Article
- Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals.Frontiers in systems neuroscience · 2015Review
- Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry.Molecular and cellular neurosciences · 2014Article
- Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control.Physiology & behavior · 2013Review
- ATP-sensitive potassium channels mediate the thermosensory response of orexin neurons.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The hypocretin/orexin (Hcrt)-containing neurones within the lateral hypothalamus integrate nutritional, energetic and behavioural cues to generate the final output in order to exert their functions. It is still not clear how Hcrt neurones monitor changes in energy status in animals. In brain slices from transgenic mice expressing green fluorescent protein (GFP) exclusively in Hcrt neurones, we examined the roles of intracellular levels of ATP ([ATP](i)) in regulating activities in these cells with conventional and perforated whole-cell recording. By using 'ATP clamp' we demonstrated that membrane potential (V(m)) correlated with the [ATP](i) in Hcrt neurones. Perforated recording revealed a V(m) of -46.1 ± 1.6 mV (n = 18), close to the level measured with an [ATP](i) equal to 5-6 mm (-48.7 ± 1.4 mV, n = 16, 5 mm ATP), suggesting that a unique demand for energy is required to maintain normal functionality in Hcrt cells. A direct disruption of ATP production or reduction in ambient glucose levels resulted in an inhibition of activity in Hcrt neurones. The V(m) was significantly depolarized in Hcrt neurones in sleep-deprived mice as compared with controls (P < 0.01, t test), which was eliminated by experimental manipulations causing the same level of [ATP](i) and K(ATP) channel opening in both groups, suggesting a decrease during sleep and an increase during sustained wakefulness in [ATP](i) in Hcrt cells. In summary, these data demonstrate that a delicate control of activity by monitoring the availability of intracellular energy stores in Hcrt cells may serve as a novel mechanism regulating energy expenditure and behavioural state dependent upon the energy state in animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.