ReviewExperimental biology and medicine (Maywood, N.J.)2011
Genome-wide screening using RNA interference to study host factors in viral replication and pathogenesis.
Review in Experimental biology and medicine (Maywood, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Screening Drugs for Broad-Spectrum, Host-Directed Antiviral Activity: Lessons from the Development of Probenecid for COVID-19.Viruses · 2023Article
- Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies.Frontiers in microbiology · 2022Review
- Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro.Scientific reports · 2021Article
- Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry.Nature communications · 2021Article
- Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors.Journal of visualized experiments : JoVE · 2018Article
- Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy.Journal of visualized experiments : JoVE · 2018Article
- Human Kinase/Phosphatase-Wide RNAi Screening Identified Checkpoint Kinase 2 as a Cellular Factor Facilitating Japanese Encephalitis Virus Infection.Frontiers in cellular and infection microbiology · 2018Article
- Article
- Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection.Journal of virology · 2016Article
- RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load.Current genomics · 2015Article
- SRSF1 inhibition of HIV-1 gene expression.Oncotarget · 2015Article
- The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.Scientific reports · 2015Article
- An integrative approach for a network based meta-analysis of viral RNAi screens.Algorithms for molecular biology : AMB · 2015Article
- Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.Retrovirology · 2014Article
- Article
- Article
- Human enterovirus 71 epidemics: what's next?Emerging health threats journal · 2013Review
- NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression.mBio · 2013Article
- MicroRNAs and HIV-1: complex interactions.The Journal of biological chemistry · 2012Review
- Functional genomic and high-content screening for target discovery and deconvolution.Expert opinion on drug discovery · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
With the recent development of short interfering RNA and short hairpin RNA expression libraries, RNA interference (RNAi) technology has been extensively employed to identify genes involved in diverse cellular processes, such as signal transduction, cell cycle, cancer biology and host-pathogen interactions. In the field of viral infection, this approach has already identified hundreds of new genes not previously known to be important for various virus lifecycles. In this brief review, we focus on recent studies performed using genome-wide RNAi-based screens in mammalian cells for the identification of essential host factors for viral infection and pathogenesis.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.