ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2011
Transcription factor heterogeneity and epiblast pluripotency.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Hemichordate cis-regulatory genomics and the gene expression dynamics of deuterostomes.Nature ecology & evolution · 2024Article
- The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development.Biochemical Society transactions · 2024Review
- A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma.Cell communication and signaling : CCS · 2024Article
- Regulation of Oct4 in stem cells and neural crest cells.Birth defects research · 2022Review
- Retinoic acid signaling is critical during the totipotency window in early mammalian development.Nature structural & molecular biology · 2021Article
- Article
- Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma.Journal of cellular physiology · 2020Article
- Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state.Biology open · 2018Article
- Article
- Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2.Developmental cell · 2017Article
- Nanog, Oct4 and Tet1 interplay in establishing pluripotency.Scientific reports · 2016Article
- The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.Genes & development · 2016Article
- The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.Cell stem cell · 2013Article
- The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states.Current opinion in genetics & development · 2013Review
- Generation and characterization of a novel mouse embryonic stem cell line with a dynamic reporter of Nanog expression.PloS one · 2013Article
- DeGNServer: deciphering genome-scale gene networks through high performance reverse engineering analysis.BioMed research international · 2013Article
- Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells.Cell stem cell · 2012Article
- Probing the role of stochasticity in a model of the embryonic stem cell: heterogeneous gene expression and reprogramming efficiency.BMC systems biology · 2012Article
- Contribution of stochastic partitioning at human embryonic stem cell division to NANOG heterogeneity.PloS one · 2012Article
- The evolving biology of cell reprogramming.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells are defined by the simultaneous possession of the seemingly incongruent properties of self-renewal and multi-lineage differentiation potential. To maintain a stem cell population, these opposing forces must be balanced. Transcription factors that function to direct pluripotent cell identity are not all equally distributed throughout the pluripotent cell population. While Oct4 levels are relatively homogeneous, other transcription factors, such as Nanog, are more heterogeneously expressed. Moreover, Oct4 positive cells fluctuate between states of high Nanog expression associated with a high probability of self-renewal and low Nanog expression associated with an increased propensity to differentiate. As embryonic stem (ES) cells transit to the more developmentally advanced epiblast stem cell (EpiSC) state, the levels of pluripotency transcription factors are modulated. Such modulations are blunted in cells that overexpress Nanog and this may underlie the resistance of Nanog-overexpressing cells to transit to an EpiSC state. Interestingly, increasing the levels of Nanog in EpiSC can facilitate reversion to the ES cell state. Together these observations suggest that Nanog lies close to the top of the hierarchy of pluripotent transcription factor regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.