ArticleAtherosclerosis2011
The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations.
Article in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.European journal of human genetics : EJHG · 2019Pooled it
- Association of NFKB1 gene polymorphism (rs28362491) with cardiometabolic risk factor in patients undergoing coronary angiography.Journal of cardiovascular and thoracic research · 2023Article
- Association of NFKB1 gene rs28362491 mutation with the occurrence of major adverse cardiovascular events.BMC cardiovascular disorders · 2022Article
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- Association ofBalkan journal of medical genetics : BJMG · 2021Article
- HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- NFKB1 gene rs28362491 ins/del variation is associated with higher susceptibility to myocardial infarction in a Chinese Han population.Scientific reports · 2020Article
- NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome.Bioscience reports · 2019Article
- Vitamin D Deficiency Harms Patients with Coronary Heart Disease by Enhancing Inflammation.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The promoter polymorphism ofJournal of exercise rehabilitation · 2018Article
- The association betweenMolecular biology research communications · 2018Article
- Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population.Journal of epidemiology · 2017Article
- Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease.Biomedical reports · 2015Article
- Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population.International journal of clinical and experimental medicine · 2015Article
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- Article
- Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population.PloS one · 2015Article
- -94 ATTG insertion/deletion polymorphism of the NFKB1 gene is associated with coronary artery disease in Han and Uygur women in China.Genetic testing and molecular biomarkers · 2014Article
- Article
- Integrated analysis of microarray data of atherosclerotic plaques: modulation of the ubiquitin-proteasome system.PloS one · 2014Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
aimInflammation is a risk factor for coronary heart disease (CHD). A common deletion-allele in the promoter region of NFKB1 results in lower protein levels of the NF-κB p50 subunit. Recent evidence suggests that the NF-κB p50 dimer has anti-inflammatory effects. We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND
resultsThe NFKB1 ins/del polymorphism was genotyped in studies of CHD nested within the Diet, Cancer and Health (DCH) study, the Health Professionals Follow-up (HPFS) and the Nurses' Health (NHS) studies, totaling 1008, 428 and 439 cases, respectively. The minor allele frequency in the combined sample was 0.38 among controls. In a pooled analysis, the relative risk (RR) among heterozygous men and women was 1.22 (95% CI: 1.07-1.40), compared to the most common ins/ins genotype. The RR among homozygotes was 1.20 (95% CI: 0.94-1.53). There was no evidence of an allele-dosage effect, and in a dominant model the RR among del-allele carriers was 1.22 (95% CI: 1.07-1.39). The risk was similar in women and men (RR was 1.20 in women and 1.23 in men, respectively). The NFKB1 variant was not associated with plasma lipid levels, but del-carriers had lower levels of C-reactive protein.
conclusionsThe NFKB1 promoter variant, previously shown to cause partial depletion of NF-κB p50, was associated with a higher risk of CHD in three independent prospective studies of generally healthy Caucasians.
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