ArticleDevelopment genes and evolution2011
Identification and expression analysis of the zebrafish orthologue of Klotho.
Article in Development genes and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models.Current osteoporosis reports · 2024Review
- A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese Transporter.Research (Washington, D.C.) · 2024Article
- Loss of αklotho causes reduced motor ability and short lifespan in zebrafish.Scientific reports · 2021Article
- αKlotho-FGF23 interactions and their role in kidney disease: a molecular insight.Cellular and molecular life sciences : CMLS · 2019Review
- Subtle Difference Generates Big Dissimilarity: Comparison of Enzymatic Activity in KL1 and KL2 Domains of Lancelet Klotho.Marine biotechnology (New York, N.Y.) · 2019Article
- Phylogenetic analysis and expression profiling of the Klotho gene family in the short-lived African killifish Nothobranchius furzeri.Development genes and evolution · 2018Article
- Molecular basis of Klotho: from gene to function in aging.Endocrine reviews · 2015Review
- Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klotho is an aging suppressor gene. In mice, loss of Klotho function causes accelerated aging while increased Klotho expression increases longevity. This study aimed to identify and characterize the orthologue of Klotho in zebrafish, a powerful model organism for the investigation of development and human disease. Zebrafish klotho was identified by a bioinformatics approach, and cloning and sequencing of klotho cDNA confirmed the in silico analysis. The zebrafish Klotho protein has a structure similar to human and mouse Klotho, but it lacks an apparent secretory signal sequence. We can find no evidence of an alternative transcript isoform lacking the transmembrane domain coding sequence as seen in mammals. RT-PCR revealed the expression of klotho during embryonic development and in a wider variety of adult tissues than in mouse. Quantitative real-time RT-PCR demonstrated the relative gene expression profile of zebrafish Klotho during embryogenesis and in adult tissues. In situ hybridization showed an apparently diffuse signal of klotho mRNA expression in the adult zebrafish testis.
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Registered trials
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