Evidence map›Paper›PMID 21725858›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2011

Biomarkers of structural remodelling and endothelial dysfunction for prediction of cardiovascular events or death in patients with atrial fibrillation.

Joachim R Ehrlich, Magdalena Kaluzny, Stefan Baumann, Ralf Lehmann, Stefan H Hohnloser

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Biomarkers in electrophysiology: role in arrhythmias and resynchronization therapy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015
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  15. Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation.Medical science monitor : international medical journal of experimental and clinical research · 2014
    Article
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  19. Atrial fibrillation, elevated troponin, ischemic stroke and adverse outcomes: understanding the connection.Clinical research in cardiology : official journal of the German Cardiac Society · 2013
    Article
  20. Erectile dysfunction may be the first clinical sign of insulin resistance and endothelial dysfunction in young men.Clinical research in cardiology : official journal of the German Cardiac Society · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joachim R EhrlichDivision of Cardiology, Section of Electrophysiology, Goethe-University, Frankfurt, Germany.
Magdalena Kaluzny
Stefan Baumann
Ralf Lehmann
Stefan H Hohnloser

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAtrial fibrillation (AF) is associated not only with inflammation but also with structural remodelling and altered endothelial activation which may contribute to clot formation, embolization and mortality. We aimed to determine the predictive value of single-time biomarker analysis for prediction of outcome in patients with AF. METHODS AND

resultsWe conducted a prospective study to evaluate if biomarkers of structural, electrical or endothelial remodelling are predictive of cardiovascular events (composite primary endpoint of myocardial infarction, stroke, peripheral embolism or death). Secondary endpoint was all-cause mortality. Patients with any type of AF and without active inflammatory conditions were eligible. Plasma samples were collected for ELISA analysis of biomarkers (inflammation [hsCRP, sCD40L], structural [MMP-2] and endothelial remodelling [vWF, sVCAM-1]) at enrolment. Patients (n = 278) were followed for 28 ± 12 (median 32) months. Eighty-eight individuals (32%) experienced a primary outcome event, including 8 (2.9%) with myocardial infarction, 13 (4.8%) with stroke and 4 (1.5%) with peripheral embolism. Predictors of the primary endpoint were age >75 years, CHADS(2)-score >2, LVEF <35%, diabetes, presence of an ICD/pacemaker, elevated vWF, sVCAM-1 and MMP-2 levels. On multivariate regression analysis, only age >75 years, sVCAM-1 and MMP-2 levels remained independently associated with the endpoint. There were 75 deaths during follow-up. Age >75 years, reduced LVEF, elevated sVCAM-1 and MMP-2 levels were predictors of all-cause mortality.

conclusionIn this cohort of AF patients, old age, elevated sVCAM-1 and MMP-2 levels were associated with cardiovascular events. Our data indicate that single-time biomarker assessment may be a useful tool to improve risk stratification schemes.

Indexed as

Ventricular RemodelingAgedAged, 80 and overAge FactorsAtrial FibrillationBiomarkersCardiovascular DiseasesCD40 LigandC-Reactive ProteinEndothelium, VascularEnzyme-Linked Immunosorbent AssayFemaleGermanyHumansKaplan-Meier EstimateMaleBiomarkersCD40 LigandC-Reactive ProteinMatrix Metalloproteinase 2MMP2 protein, humanVascular Cell Adhesion Molecule-1von Willebrand Factor

Identifiers

PMID21725858

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.