Trial reportJournal of anesthesia2011
Flurbiprofen axetil enhances analgesic effect of fentanyl associated with increase in β-endorphin levels.
Trial report in Journal of anesthesia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Preoperative flurbiprofen axetil administration for acute postoperative pain: a meta-analysis of randomized controlled trials.Journal of anesthesia · 2017Pooled it
- Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Effect of flurbiprofen axetil on postoperative delirium for elderly patients.Brain and behavior · 2019Trial
- Trial
- Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery.Mediators of inflammation · 2015Trial
- New insight into the analgesic recipe: A cohort study based on smart patient-controlled analgesia pumps records.Frontiers in pharmacology · 2022Article
- Postoperative analgesia using fentanyl plus celecoxib versus epidural anesthesia after laparoscopic colon resection.Surgery today · 2017Article
- A novel injection strategy of flurbiprofen axetil by inhibiting protein binding with 6-methoxy-2-naphthylacetic acid.European journal of drug metabolism and pharmacokinetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine the analgesic effect of preoperative administration of flurbiprofen axetil and that of postoperative administration of a combination of flurbiprofen axetil and fentanyl, as well as perioperative plasma β-endorphin (β-EP) levels in patients undergoing esophagectomy.
methodsForty-five patients were randomly divided into three groups: group A: 100 mg flurbiprofen axetil preoperative, 10 μg/kg fentanyl + 10 ml placebo postoperative; group B: 100 mg flurbiprofen axetil preoperative, 10 μg/kg fentanyl + 100 mg flurbiprofen axetil postoperative; group C: 10 ml placebo preoperative, 10 μg/kg fentanyl + 10 ml placebo postoperative. Postoperative analgesia was achieved by intravenous infusion containing flurbiprofen axetil and/or fentanyl at 2.0 ml/h (total volume, 100 ml) using infusion pumps. The β-EP was measured at preanesthesia (T(1)), the end of surgery (T(2)), 24 h (T(3)), and 48 h (T(4)) after surgery. Visual analog scale scores (VAS) at T3, T4 (at rest), and rescue analgesic tramadol requirement was recorded.
resultsThe VAS of group B was significantly lower than group A and C (P < 0.01) at T(3) and T(4). The β-EP levels at T(2)-T(4) in group A did not differ significantly from those at T(1) (P > 0.05); however, the β-EP levels in group B at T(3)-T(4) increased significantly (P < 0.05), while those in group C increased at T(2) and decreased at T(4) (P < 0.05). The β-EP levels in group B at T(3) and T(4) were the highest as compared to its levels in groups A and C (P < 0.01). Tramadol consumption in group B was significantly lower than in groups A and C (P < 0.01).
conclusionThese results show that flurbiprofen axetil enhances the analgesic effect of fentanyl associated with increase in β-EP levels.
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