ArticleEuropean journal of nutrition2012
High-fat diets affect energy and bone metabolism in growing rats.
Article in European journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of fried sunflower oil intake on mandibular biomechanical competence of growing rats.Acta odontologica latinoamericana : AOL · 2023Article
- Magnesium Picolinate Improves Bone Formation by Regulation of RANK/RANKL/OPG and BMP-2/Runx2 Signaling Pathways in High-Fat Fed Rats.Nutrients · 2021Article
- Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.International journal of molecular sciences · 2021Review
- Early Nutrition during Hospitalization in Relation to Bone Health in Preterm Infants at Term Age and Six Months Corrected Age.Nutrients · 2021Article
- A diet high in fat and fructose adversely affects osseointegration of titanium implants in rats.Clinical and experimental dental research · 2020Article
- Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice.Bone · 2019Article
- Diet-induced obesity suppresses cortical bone accrual by a neuropeptide Y-dependent mechanism.International journal of obesity (2005) · 2018Article
- High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice.Journal of cellular physiology · 2018Article
- Effects of metabolic syndrome on bone mineral density, histomorphometry and remodelling markers in male rats.PloS one · 2018Article
- Fat, Sugar, and Bone Health: A Complex Relationship.Nutrients · 2017Review
- High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice.Nutrition research (New York, N.Y.) · 2016Article
- Article
- Gene-dietary fat interaction, bone mineral density and bone speed of sound in children: a twin study in China.Molecular nutrition & food research · 2015Article
- Maternal high fat feeding does not have long-lasting effects on body composition and bone health in female and male Wistar rat offspring at young adulthood.Molecules (Basel, Switzerland) · 2013Article
- Investigating the role of polyunsaturated fatty acids in bone development using animal models.Molecules (Basel, Switzerland) · 2013Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-fat diets are usually associated with greater weight (W) gain and body fat (BF). However, it is still unclear whether the type and amount of fat consumed influence BF. Additionally, dietary fat intake may also have consequences on skeletal health.
objectiveTo evaluate in healthy growing rats the effects of high-fat diets and type of dietary fat intake (saturated or vegetable oils) on energy and bone metabolism.
methodsAt weaning, male Wistar rats (n = 50) were fed either a control diet (C; fat = 7% w/w) or a high-fat diet (20% w/w) containing either: soybean oil, corn oil (CO), linseed oil (LO), or beef tallow (BT) for 8 weeks. Zoometric parameters, BF, food intake and digestibility, and total and bone alkaline phosphatase (b-AP) were assessed. Total skeleton bone mineral density (BMD) and content (BMC), BMC/W, spine BMD, and bone volume (static-histomorphometry) were measured.
resultsAnimals fed BT diet achieved lower W versus C. Rats fed high-fat vegetable oil diets showed similar effects on the zoometric parameters but differed in BF. BT showed the lowest lipid digestibility and BMC. In contrast, high vegetable oil diets produced no significant differences in BMC, BMC/W, BMD, spine BMD, and bone volume. Marked differences were observed for LO and BT groups in b-AP and CO and BT groups in bone volume.
conclusionBT diet rich in saturated fatty acids had decreased digestibility and adversely affected energy and bone metabolisms, in growing healthy male rats. There were no changes in zoometric and bone parameters among rats fed high vegetable oil diets.
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