ArticleThe Journal of physiology1990
Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes.
Article in The Journal of physiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 92 citations in OpenAlex.
- Mechanisms underlying local CaThe Journal of physiology · 2025Article
- Reduced O-GlcNAcylation diminishes cardiomyocyte CaJournal of molecular and cellular cardiology · 2023Article
- Regulation of Cardiac Cav1.2 Channels by Calmodulin.International journal of molecular sciences · 2023Review
- Calmodulinopathy: Functional Effects of CALM Mutations and Their Relationship With Clinical Phenotypes.Frontiers in cardiovascular medicine · 2018Review
- Ca2+-dependent modulation of voltage-gated Ca2+ channels.Biochimica et biophysica acta · 2012Review
- CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.The Journal of cell biology · 2005Article
- Na(+)-Ca2+ exchange function underlying contraction frequency inotropy in the cat myocardium.The Journal of physiology · 2003Article
- Inactivation of ICa-L is the major determinant of use-dependent facilitation in rat cardiomyocytes.The Journal of physiology · 2003Article
- Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes.The Journal of physiology · 2002Article
- Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels.Biophysical journal · 2000Article
- Facilitation of the presynaptic calcium current at an auditory synapse in rat brainstem.The Journal of physiology · 1998Article
- Structures and functions of calcium channel beta subunits.Journal of bioenergetics and biomembranes · 1998Review
- Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Calcium currents, transmitter release and facilitation of release at voltage-clamped crayfish nerve terminals.The Journal of physiology · 1996Article
- Multiple components of Ca2+ channel facilitation in cerebellar granule cells: expression of facilitation during development in culture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Facilitation of T-type calcium current in bullfrog atrial cells: voltage-dependent relief of a G protein inhibitory tone.The Journal of physiology · 1996Article
- Regulation of Ca channel by intracellular Ca2+ and Mg2+ in frog ventricular cells.Pflugers Archiv : European journal of physiology · 1996Article
- Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Dual modulation of unitary L-type Ca2+ channel currents by [Ca2+]i in fura-2-loaded guinea-pig ventricular myocytes.The Journal of physiology · 1994Article
- Regulation of the frequency-dependent facilitation of L-type Ca2+ currents in rat ventricular myocytes.The Journal of physiology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. Stimulation-dependent modulation of Ca currents was examined in guinea-pig ventricular myocytes at room temperature. Whole-cell recordings of Ca currents were made under conditions which minimized ionic fluxes through other channels. 2. Stimulation from rest at a rate of 2 Hz resulted in a decrease of the low threshold Ca current within one pulse and facilitation of the high threshold Ca current within five pulses. Facilitation was associated with a reduction in the rate of inactivation. 3. Pulse durations as short as 10 ms facilitated the high threshold Ca current in subsequent pulses. Facilitation produced by a single pulse decayed with a half-time of several seconds. 4. Substitution of Ba2+ or Sr2+ for external Ca2+ reduced the rate of inactivation of the high threshold Ca current and abolished facilitation of the current. 5. Facilitation persisted with 40 microM-Ruthenium Red added to the internal solution or 0.2-2 microM-ryanodine added to the bath solution to reduce Ca2+ release from the sarcoplasmic reticulum. 6. Facilitation was modulated by isoprenaline. Low concentrations of isoprenaline (5-10 nM) increased the amount of facilitation. Isoprenaline (1 microM) increased the Ca current approximately 3-fold, however, facilitation was nearly abolished. 7. Caffeine (0.5 and 1 mM) affected the Ca current and facilitation in a manner similar to 1 microM-isoprenaline. It increased the Ca currents approximately 2.5-fold and facilitation was not observed. 8. We conclude that stimulation-dependent facilitation of the high threshold Ca current is mediated by calcium and hypothesize that calcium affects a site near the Ca channel that modifies the rate of inactivation. The common actions of caffeine and high concentrations of isoprenaline suggest that calcium modulates a phosphorylation step.
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