ArticleCurrent opinion in neurology2011
The prominent role of stimulus processing: cholinergic function and dysfunction in cognition.
Article in Current opinion in neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Potential of pretreatment neural activity in the visual cortex during emotional processing to predict treatment response to scopolamine in major depressive disorder.JAMA psychiatry · 2013Trial
- Cholinergic enhancement reduces functional connectivity and BOLD variability in visual extrastriate cortex during selective attention.Neuropharmacology · 2013Trial
- DECIDE-CTA: A designer-empowered method for creating structured cognitive task analyses from product instructions.MethodsX · 2026Article
- Cross-diagnostic determinants of cognitive functioning: the muscarinic cholinergic receptor as a model system.Translational psychiatry · 2023Review
- The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review.Brain sciences · 2022Review
- Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice.Scientific reports · 2021Article
- Scopolamine Reduces Electrophysiological Indices of Distractor Suppression: Evidence from a Contingent Capture Task.Frontiers in neural circuits · 2017Article
- Amygdala response to explicit sad face stimuli at baseline predicts antidepressant treatment response to scopolamine in major depressive disorder.Psychiatry research. Neuroimaging · 2016Article
- Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Article
- Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depression: A Model-Based Approach.Frontiers in psychology · 2016Article
- Pretreatment Differences in BOLD Response to Emotional Faces Correlate with Antidepressant Response to Scopolamine.The international journal of neuropsychopharmacology · 2015Article
- Boosting visual cortex function and plasticity with acetylcholine to enhance visual perception.Frontiers in systems neuroscience · 2014Review
- A biased competition account of attention and memory in Alzheimer's disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.Psychopharmacology · 2013Review
- Molecular imaging as a guide for the treatment of central nervous system disorders.Dialogues in clinical neuroscience · 2013Review
- Pulsed intravenous administration of scopolamine produces rapid antidepressant effects and modest side effects.The Journal of clinical psychiatry · 2013Review
- Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review.Biological psychiatry · 2013Review
- Human biomarkers of rapid antidepressant effects.Biological psychiatry · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
purpose of reviewThe present review develops a framework from which to understand the role of the cholinergic system in healthy cognition and in cognitive dysfunction. Traditionally, the cholinergic system has been thought to have direct influence on cognitive processes such as working memory and attention. Although the influence of cholinergic function on stimulus processing has been long appreciated, the notion that cholinergic effects on stimulus processing is the mechanism by which acetylcholine influences cognitive processes has only more recently been considered. RECENT
findingsLiterature supporting the hypothesis that cholinergic modulation influences cognitive functions through stimulus processing mechanisms has been growing for over a decade. Recent conceptualizations of the developing literature have argued for a new interpretation to an old and developing literature. SUMMARY: The argument that cholinergic function modulates cognitive processes by direct effects on basic stimulus processing extends to cognitive dysfunction in neuropathological conditions including dementia and mood disorders. Memory and attention deficits observed in these and other conditions can be understood by evaluating the impact of cholinergic dysfunction on stimulus processing, rather than on the cognitive function in general.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.