ArticleBiofabrication2011
Microengineering methods for cell-based microarrays and high-throughput drug-screening applications.
Article in Biofabrication, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Article
- Droplet microarray platforms for high-throughput drug screening.Mikrochimica acta · 2023Review
- Application of microfluidic chips in anticancer drug screening.Bosnian journal of basic medical sciences · 2022Review
- The impact of microfluidics in high-throughput drug-screening applications.Biomicrofluidics · 2022Review
- Flipped Well-Plate Hanging-Drop Technique for Growing Three-Dimensional Tumors.Frontiers in bioengineering and biotechnology · 2022Article
- Advances on Bone Substitutes through 3D Bioprinting.International journal of molecular sciences · 2020Review
- Acoustic Patterning of Growth Factor for Three-Dimensional Tissue Engineering.Tissue engineering. Part A · 2020Article
- Evaluation of the effects of cell-dispensing using an inkjet-based bioprinter on cell integrity by RNA-seq analysis.Scientific reports · 2020Article
- Effects of Cryopreservation on Cell Metabolic Activity and Function of Biofabricated Structures Laden with Osteoblasts.Materials (Basel, Switzerland) · 2020Article
- Paper-Based Electrochemical Devices for the Pharmaceutical Field: State of the Art and Perspectives.Frontiers in bioengineering and biotechnology · 2020Review
- Recent advances in microfluidics for drug screening.Biomicrofluidics · 2019Review
- Application of microfluidic chip technology in pharmaceutical analysis: A review.Journal of pharmaceutical analysis · 2019Article
- A Plug-and-Play, Drug-on-Pillar Platform for Combination Drug Screening Implemented by Microfluidic Adaptive Printing.Analytical chemistry · 2018Article
- Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems.AAPS PharmSciTech · 2018Article
- Controlled self-assembly of alginate microgels by rapidly binding molecule pairs.Lab on a chip · 2017Article
- Cell Microarray Technologies for High-Throughput Cell-Based Biosensors.Sensors (Basel, Switzerland) · 2017Review
- Tissue Engineering Approaches in the Design of Healthy and PathologicalFrontiers in bioengineering and biotechnology · 2017Review
- Engineering a Brain Cancer Chip for High-throughput Drug Screening.Scientific reports · 2016Article
- Screening applications in drug discovery based on microfluidic technology.Biomicrofluidics · 2016Review
- Engineering cancer microenvironments forMaterials today (Kidlington, England) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Screening for effective therapeutic agents from millions of drug candidates is costly, time consuming, and often faces concerns due to the extensive use of animals. To improve cost effectiveness, and to minimize animal testing in pharmaceutical research, in vitro monolayer cell microarrays with multiwell plate assays have been developed. Integration of cell microarrays with microfluidic systems has facilitated automated and controlled component loading, significantly reducing the consumption of the candidate compounds and the target cells. Even though these methods significantly increased the throughput compared to conventional in vitro testing systems and in vivo animal models, the cost associated with these platforms remains prohibitively high. Besides, there is a need for three-dimensional (3D) cell-based drug-screening models which can mimic the in vivo microenvironment and the functionality of the native tissues. Here, we present the state-of-the-art microengineering approaches that can be used to develop 3D cell-based drug-screening assays. We highlight the 3D in vitro cell culture systems with live cell-based arrays, microfluidic cell culture systems, and their application to high-throughput drug screening. We conclude that among the emerging microengineering approaches, bioprinting holds great potential to provide repeatable 3D cell-based constructs with high temporal, spatial control and versatility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.