ArticleBiofabrication2011
Laser-guidance-based cell deposition microscope for heterotypic single-cell micropatterning.
Article in Biofabrication, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Study of the Expression Transition of Cardiac Myosin Using Polarization-Dependent SHG Microscopy.Biophysical journal · 2020Article
- Changes in the crystallographic structures of cardiac myosin filaments detected by polarization-dependent second harmonic generation microscopy.Biomedical optics express · 2019Article
- Cell Deposition Microchip with Micropipette Control over Liquid Interface Motion.Cell medicine · 2018Article
- Microfluidics-based laser cell-micropatterning system.Biofabrication · 2014Article
- Myosin filament assembly onto myofibrils in live neonatal cardiomyocytes observed by TPEF-SHG microscopy.Cardiovascular research · 2013Article
- Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level.Light, science & applications · 2013Article
- Mesenchymal stem cell-cardiomyocyte interactions under defined contact modes on laser-patterned biochips.PloS one · 2013Article
- Quantitatively analyzing the protective effect of mesenchymal stem cells on cardiomyocytes in single-cell biochips.Biotechnology letters · 2012Article
- Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses.Lab on a chip · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cell patterning methods enable researchers to control specific homotypic and heterotypic contact-mediated cell-cell and cell-ECM interactions and to impose defined cell and tissue geometries. To micropattern individual cells to specific points on a substrate with high spatial resolution, we have developed a cell deposition microscope based on the laser-guidance technique. We discuss the theory of optical forces for generating laser guidance and the optimization of the optical configuration (NA ≈ 0.1) to manipulate cells with high speed in three dimensions. Our cell deposition microscope is capable of patterning different cell types onto and within standard cell research devices and providing on-stage incubation for long-term cell culturing. Using this cell deposition microscope, rat mesenchymal stem cells from bone marrow were micropatterned with cardiomyocytes into a substrate microfabricated with polydimethylsiloxane on a 22 mm × 22 mm coverglass to form a single-cell coculturing microenvironment, and their electrophysiological property changes were investigated during the coculturing days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.