ArticleJournal of bacteriology2011
The σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureus.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Stage V sporulation protein G as a global regulator of biofilm formation and virulence in Staphylococcus species: molecular mechanisms and therapeutic potential.World journal of microbiology & biotechnology · 2026Review
- The phage Φ13-encoded transcriptional regulator Ltr controls phage assembly in Staphylococcus aureus.Virology journal · 2026Article
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- Insights into the regulatory role of bacterial sncRNA and its extracellular delivery via OMVs.Applied microbiology and biotechnology · 2024Review
- The genesApplied and environmental microbiology · 2024Article
- GlutamateJournal of bacteriology · 2024Article
- CodY: An Essential Transcriptional Regulator Involved in Environmental Stress Tolerance in FoodborneFoods (Basel, Switzerland) · 2023Article
- The Transcription Factor SpoVG Is of Major Importance for Biofilm Formation ofInternational journal of molecular sciences · 2022Article
- The Q225P Mutation in SigB Promotes Membrane Vesicle Formation in Staphylococcus aureus.Current microbiology · 2022Article
- SpoVG is an important regulator of sporulation and affects biofilm formation by regulating Spo0A transcription in Bacillus cereus 0-9.BMC microbiology · 2021Article
- SpoVG Modulates Cell Aggregation in Staphylococcus aureus by RegulatingApplied and environmental microbiology · 2020Article
- Alternative Sigma Factor B in Bovine Mastitis-CausingFrontiers in microbiology · 2019Article
- A novel chlorination-induced ribonuclease YabJ fromBioscience reports · 2018Article
- Influence of subinhibitory concentrations of NH125 on biofilm formation & virulence factors of Staphylococcus aureus.Future medicinal chemistry · 2018Article
- A novel SigB(Q225P) mutation in Staphylococcus aureus retains virulence but promotes biofilm formation.Emerging microbes & infections · 2018Article
- Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance.Scientific reports · 2018Article
- Resilience in the Face of Uncertainty: Sigma Factor B Fine-Tunes Gene Expression To Support Homeostasis in Gram-Positive Bacteria.Applied and environmental microbiology · 2016Review
- SpoVG Regulates Cell Wall Metabolism and Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus Strain N315.Antimicrobial agents and chemotherapy · 2016Article
- Article
- Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.PLoS genetics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The alternative sigma factor σ(B) of Staphylococcus aureus is involved in the coordination of the general stress response, expression of virulence determinants, and modulation of antibiotic resistance levels. It controls a large regulon, either directly by recognizing conserved σ(B) promoter sequences or indirectly via σ(B)-dependent elements. The σ(B)-controlled yabJ-spoVG operon encodes two such putative downstream elements. We report here transcriptome analysis in S. aureus Newman, showing that inactivation of the yabJ-spoVG operon had primarily a repressing effect on a small subregulon encoding mainly virulence factors, including a nuclease (nuc), a protease (splE) and a lipase (lip). As a consequence, extracellular nuclease, protease, and lipase activities were reduced in a ΔyabJ-spoVG mutant. trans-complementation by SpoVG was sufficient to restore their reduced phenotypic expression and lowered transcription due to the yabJ-spoVG deletion. It did not restore, however, the changes triggered by σ(B) inactivation, indicating that both regulons only partially overlap, despite the σ(B) dependency of the yabJ-spoVG expression. Thus, σ(B) is likely to control additional, SpoVG-independent factors affecting the expression of numerous hydrolytic enzymes. SpoVG, on the other hand, seems to fine-tune the σ(B)-dependent regulation of a subset of virulence factors by antagonizing the σ(B) effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.