ArticleAmerican journal of physiology. Lung cellular and molecular physiology2011
NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65.
Article in American journal of physiology. Lung cellular and molecular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Toll-like receptors in innate immunity and inflammation: from fundamental biology to clinic insights.Immunity & inflammation · 2026Review
- Dissecting the opposing regulatory functions of endogenous nitric oxide production in colorectal cancer initiation, adaptive immune response alterations, and ferroptosis execution.Oncology reviews · 2025Review
- Transcriptomic landscape of hepatic lymph nodes, peripheral blood lymphocytes and spleen of swamp buffaloes infected with the tropical liver fluke Fasciola gigantica.PLoS neglected tropical diseases · 2022Article
- Article
- Role of NO and S-nitrosylation in the Expression of Endothelial Adhesion Proteins That Regulate Leukocyte and Tumor Cell Adhesion.Frontiers in physiology · 2020Review
- Consequences of Hypoxia for the Pulmonary Alveolar Epithelial Cell Innate Immune Response.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- TXNIP/TRX/NF-κB and MAPK/NF-κB pathways involved in the cardiotoxicity induced by Venenum Bufonis in rats.Scientific reports · 2016Article
- Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology-A Review.Oxidative medicine and cellular longevity · 2016Review
- S-Nitrosylation in TNF superfamily signaling pathway: Implication in cancer.Redox biology · 2015Review
- Nitrosothiol signaling and protein nitrosation in cell death.Nitric oxide : biology and chemistry · 2014Review
- Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation.The Journal of biological chemistry · 2014Article
- Proteomic analysis of the NOS2 interactome in human airway epithelial cells.Nitric oxide : biology and chemistry · 2013Article
- Redox control of inflammation in macrophages.Antioxidants & redox signaling · 2013Review
- Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin.Toxicology and applied pharmacology · 2013Article
- A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations.Human genetics · 2013Article
- The effect of endogenous angiotensin II on alveolar fluid clearance in rats with acute lung injury.Canadian respiratory journalArticle
Corrections and comments
- Erratum issuedCorrigendum.2016
Authors and funding
7 authors.
Funding
Abstract
Inducible nitric oxide synthase (NOS2) expression is increased in the airway epithelium in acute inflammatory disorders although the physiological impact remains unclear. We have previously shown that NOS2 inhibits NF-κB (p50-p65) activation in respiratory epithelial cells by inducing S-nitrosylation of the p65 monomer (SNO-p65). In addition, we have demonstrated that mouse lung SNO-p65 levels are acutely depleted in a lipopolysaccharide (LPS) model of lung injury and that augmenting SNO-p65 levels before LPS treatment results in decreased airway epithelial NF-κB activation, airway inflammation, and lung injury. We now show that aerosolized LPS induces NOS2 expression in the respiratory epithelium concomitant with an increase in lung SNO-p65 levels and a decrease in airway NF-κB activity. Genetic deletion of NOS2 results in an absence of SNO-p65 formation, persistent NF-κB activity in the respiratory epithelium, and prolonged airway inflammation. These results indicate that a primary function of LPS-induced NOS2 expression in the respiratory epithelium is to modulate the inflammatory response through deactivation of NF-κB via S-nitrosylation of p65, thereby counteracting the initial stimulus-coupled denitrosylation.
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