ArticleThorax2011
Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?
Article in Thorax, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review.Journal of environmental and public health · 2018Pooled it
- Low appendicular muscle mass and the risk of COPD development in people with PRISm.ERJ open research · 2026Article
- The independent and combined effects of smoking and chronic obstructive pulmonary disease on body mass index trajectories.Scientific reports · 2025Article
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- Muscle Mass Index Decline as a Predictor of Lung Function Reduction in the General Population.Journal of cachexia, sarcopenia and muscle · 2025Article
- High cotinine levels as an associated factor with frailty status in older adults: evidence from the NHANES study.BMC geriatrics · 2024Article
- Cigarette smoking and disproportionate changes of thoracic skeletal muscles in low-dose chest computed tomography.Scientific reports · 2023Article
- Efficacy of interventions to alter measures of fat-free mass in people with COPD: a systematic review and meta-analysis.ERJ open research · 2023Review
- Pre- and Early Peri-menopausal Physical Function and Risk of Cardiovascular Events: The Study of Women's Health Across the Nation.Journal of aging and health · 2023Article
- Characterizing the physical function decline and disabilities present among older adults with fecal incontinence: a secondary analysis of the health, aging, and body composition study.International urogynecology journal · 2022Article
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- The 2022 On-site Padua Days on Muscle and Mobility Medicine hosts the University of Florida Institute of Myology and the Wellstone Center, March 30 - April 3, 2022 at the University of Padua and Thermae of Euganean Hills, Padua, Italy: The collection of abstracts.European journal of translational myology · 2022Article
- Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment.Journal of cachexia, sarcopenia and muscle · 2022Article
- Integrating Mechanisms of Exacerbated Atrophy and Other Adverse Skeletal Muscle Impact in COPD.Frontiers in physiology · 2022Review
- Hand Grip Strength and Likelihood of Moderate-to-Severe Airflow Limitation in the General Population.International journal of chronic obstructive pulmonary disease · 2022Article
- Factors associated with mobility decrease leading to disability: a cross-sectional nationwide study in Japan, with results from 8681 adults aged 20-89 years.BMC geriatrics · 2021Article
- Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease.Respirology (Carlton, Vic.) · 2021Observational
- Retrospective analysis of exercise capacity in patients with coronary artery disease after percutaneous coronary intervention or coronary artery bypass graft.International journal of nursing sciences · 2021Article
- Respiratory exacerbations are associated with muscle loss in current and former smokers.Thorax · 2021Observational
- Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundand aims Cross-sectional studies suggest that obstructive lung disease (OLD) and smoking affect lean mass and mobility. A study was undertaken to investigate whether OLD and smoking accelerate the ageing-related decline in lean mass and physical functioning.
methods260 patients with OLD (mean±SD forced expiratory volume in 1 s (FEV1) 63±18% predicted), 157 smoking controls (FEV(1) 95±16% predicted), 866 former-smoking controls (FEV1 100±16% predicted) and 891 never-smoking controls (FEV1 104±17% predicted) participating in the Health, Aging and Body Composition (ABC) Study were studied. At baseline the mean age was 74±3 years and participants reported no functional limitations. Baseline and 7-year longitudinal data of body composition (by dual-energy x-ray absorptiometry), muscle strength (by hand and leg dynamometry) and Short Physical Performance Battery (SPPB) were investigated.
resultsCompared with never-smoking controls, patients with OLD and smoking controls had a significantly lower weight, fat mass, lean mass and bone mineral content (BMC) at baseline (p<0.05). While the loss of weight, fat mass, lean mass and strength was comparable between patients with OLD and never-smoking controls, the SPPB declined 0.12 points/year faster in men with OLD (p=0.01) and BMC declined 4 g/year faster in women with OLD (p=0.02). In smoking controls only lean mass declined 0.1 kg/year faster in women (p=0.03) and BMC 8 g/year faster in men (p=0.02) compared with never-smoking controls.
conclusionsInitially well-functioning older adults with mild-to-moderate OLD and smokers without OLD have a comparable compromised baseline profile of body composition and physical functioning, while 7-year longitudinal trajectories are to a large extent comparable to those observed in never-smokers without OLD. This suggests a common insult earlier in life related to smoking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.