Trial reportThe Journal of rheumatology2011
Matrix Gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis.
Trial report in The Journal of rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation.Journal of translational medicine · 2026Review
- The Role of Nutrition in Osteoarthritis Development.Nutrients · 2023Article
- Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis.The Journal of biological chemistry · 2023Article
- Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review.Drugs & aging · 2022Review
- Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis.International journal of molecular sciences · 2022Review
- Defining matrix Gla protein expression in the Dunkin-Hartley guinea pig model of spontaneous osteoarthritis.BMC musculoskeletal disorders · 2021Article
- Vitamin K-Dependent Proteins in Skeletal Development and Disease.International journal of molecular sciences · 2021Review
- Warfarin use and risk of knee and hip replacements.Annals of the rheumatic diseases · 2021Article
- The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence.Nutrients · 2020Review
- Vitamin K effects in human health: new insights beyond bone and cardiovascular health.Journal of nephrology · 2020Review
- Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP.Arthritis research & therapy · 2019Article
- Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption.Molecular and cellular biology · 2019Article
- Association of matrix Gla protein polymorphism and knee osteoarthritis in a chinese population.Bioscience reports · 2019Article
- Genetic association analysis of Osteopontin and Matrix Gla Protein genes polymorphisms with primary knee osteoarthritis in Mexican population.Clinical rheumatology · 2019Article
- Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.Nature reviews. Rheumatology · 2018Review
- Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.Annals of the rheumatic diseases · 2017Article
- The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis.Current nutrition reports · 2016Article
- The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study.Osteoarthritis and cartilage · 2015Article
- Association of matrix Gla protein gene functional polymorphisms with loss of bone mineral density and progression of aortic calcification.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Vitamin K deficiency is associated with incident knee osteoarthritis.The American journal of medicine · 2013Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveFactors associated with mineralization and osteophyte formation in osteoarthritis (OA) are incompletely understood. Genetic polymorphisms of matrix Gla protein (MGP), a mineralization inhibitor, have been associated clinically with conditions of abnormal calcification. We therefore evaluated the relationship of MGP concentrations and polymorphisms at the MGP locus to hand OA.
methodsOurs was an ancillary study to a 3-year randomized trial assessing the effect of vitamin K supplementation on vascular calcification and bone loss among community-dwelling elders. We studied participants who had serum MGP concentration measured and DNA genotyped for 3 MGP genetic polymorphisms (rs1800802, rs1800801, and rs4236), and who had hand radiographs. We evaluated the cross-sectional associations of serum MGP and the 3 MGP genetic polymorphisms, respectively, with radiographic hand OA using logistic regression with generalized estimating equations, adjusting for potential confounders.
resultsRadiographic hand OA in ≥ 1 joint was present in 71% of the 376 participants (mean age 74 years, mean body mass index 28 kg/m(2), 59% women). No significant association between serum MGP concentrations and radiographic hand OA was found [adjusted OR 1.0 (ref), 1.40, 1.21, and 1.21 for quartiles 1-4, respectively]. Homozygosity of the rs1800802 minor allele was associated with 0.56 times lower prevalence of hand OA compared with having ≥ 1 major allele at this locus (95% CI 0.32-0.99, p = 0.046).
conclusionThere may be an association between hand OA and genetic polymorphism at the MGP locus that is not reflected by total MGP serum concentrations. Further studies are warranted to replicate and elucidate potential mechanisms underlying these observed associations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.