ReviewCurrent opinion in microbiology2011
Iron homeostasis--Achilles' heel of Aspergillus fumigatus?
Review in Current opinion in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed.
- Apo-Transferrin Modified Natamycin-Loaded Liposomes Improve the Prognosis of Fungal Keratitis via Enhanced Antifungal and Anti-Inflammatory Activities.International journal of nanomedicine · 2026Article
- Coprogen B fromInternational journal of molecular sciences · 2025Article
- Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella.Nature communications · 2025Article
- Antimicrobial Agent Trimethoprim Influences Chemical Interactions in Cystic Fibrosis Pathogens via theACS chemical biology · 2025Article
- The transcriptional regulatorCurrent research in microbial sciences · 2025Article
- Research advances and public health strategies in China on WHO priority fungal pathogens.Mycology · 2025Review
- Development and optimization of large-scale approaches to identify iron-related genes inFrontiers in microbiology · 2025Article
- Risk factors for identifying pulmonary aspergillosis in pediatric patients.Frontiers in cellular and infection microbiology · 2025Article
- Resynthesis of Damaged Fe-S Cluster Proteins ProtectsJournal of fungi (Basel, Switzerland) · 2024Article
- Foliar mycobiome remains unaltered under urban air-pollution but differentially express stress-related genes.Microbial ecology · 2024Article
- Article
- Pathogenicity and virulence ofVirulence · 2023Review
- HapX-mediated H2B deub1 and SreA-mediated H2A.Z deposition coordinate in fungal iron resistance.Nucleic acids research · 2023Article
- Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future.The Journal of infectious diseases · 2023Review
- How metals fuel fungal virulence, yet promote anti-fungal immunity.Disease models & mechanisms · 2023Review
- Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections.Microorganisms · 2023Review
- The Siderophore Ferricrocin Mediates Iron Acquisition in Aspergillus fumigatus.Microbiology spectrum · 2023Article
- Molecular Regulatory Mechanism of the Iron-Ion-Promoted Asexual Sporulation ofJournal of fungi (Basel, Switzerland) · 2023Article
- How to Completely Squeeze a Fungus-Advanced Genome Mining Tools for Novel Bioactive Substances.Pharmaceutics · 2022Review
- Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies.Journal of clinical medicine · 2022Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial role of iron in pathophysiology, genetic inactivation of either HapX or the siderophore system attenuates virulence of A. fumigatus in a murine model of aspergillosis. The differences in iron handling between mammals and fungi might serve to improve therapy and diagnosis of fungal infections.
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Registered trials
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