ArticleThe Journal of general physiology1990
Mechanism of gating of T-type calcium channels.
Article in The Journal of general physiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System.International journal of molecular sciences · 2023Review
- Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: properties and modulation by ACTH and AngII.The Journal of general physiology · 2013Article
- Article
- A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptors.Biophysical journal · 2010Article
- Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes.Molecular and cellular endocrinology · 2009Article
- Effects of copper on T-type Ca2+ channels in mouse spermatogenic cells.The Journal of membrane biology · 2009Article
- A critical GxxxA motif in the gamma6 calcium channel subunit mediates its inhibitory effect on Cav3.1 calcium current.The Journal of physiology · 2008Article
- Quantitative modeling of currents from a voltage gated ion channel undergoing fast inactivation.PloS one · 2008Article
- Up-regulation of high voltage-activated Ca(2+) channels in GC somatotropes after long-term exposure to ghrelin and growth hormone releasing peptide-6.Cellular and molecular neurobiology · 2008Article
- Interoperability of neuroscience modeling software: current status and future directions.Neuroinformatics · 2007Review
- Evidence for common structural determinants of activation and inactivation in T-type Ca2+ channels.Pflugers Archiv : European journal of physiology · 2006Article
- The ion channel inverse problem: neuroinformatics meets biophysics.PLoS computational biology · 2006Review
- Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels.Pflugers Archiv : European journal of physiology · 2005Article
- Mechanism of arachidonic acid modulation of the T-type Ca2+ channel alpha1G.The Journal of general physiology · 2004Article
- Slow inactivation of the Ca(V)3.1 isotype of T-type calcium channels.The Journal of physiology · 2004Article
- The gating kinetics of the slow vacuolar channel. A novel mechanism for SV channel functioning?The Journal of membrane biology · 2003Article
- Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel alpha1G (CaV3.1).The Journal of general physiology · 2003Article
- Pore structure influences gating properties of the T-type Ca2+ channel alpha1G.The Journal of general physiology · 2003Article
- Mechanism of inactivation gating of human T-type (low-voltage activated) calcium channels.Biophysical journal · 2002Article
- Recovery from inactivation of t-type ca2+ channels in rat thalamic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have analyzed the gating kinetics of T-type Ca channels in 3T3 fibroblasts. Our results show that channel closing, inactivation, and recovery from inactivation each include a voltage-independent step which becomes rate limiting at extreme potentials. The data require a cyclic model with a minimum of two closed, one open, and two inactivated states. Such a model can produce good fits to our data even if the transitions between closed states are the only voltage-dependent steps in the activating pathway leading from closed to inactivated states. Our analysis suggests that the channel inactivation step, as well as the direct opening and closing transitions, are not intrinsically voltage sensitive. Single-channel recordings are consistent with this scheme. As expected, each channel produces a single burst per opening and then inactivates. Comparison of the kinetics of T-type Ca current in fibroblasts and neuronal cells reveals significant differences which suggest that different subtypes of T-type Ca channels are expressed differentially in a tissue specific manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.