ArticleBioorganic & medicinal chemistry letters2011
Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study.
Article in Bioorganic & medicinal chemistry letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Biological Potential of Oxoglaucine in Medicine for the Treatment of Human Disorders: An Update on Pharmacological Activities and Related Molecular Mechanism.Recent advances in anti-infective drug discovery · 2025Review
- Preoperative blood markers and intra-abdominal infection after colorectal cancer resection.World journal of gastrointestinal surgery · 2024Article
- Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity.Scientific reports · 2022Article
- Synthesis, In Silico and In Vivo Toxicity Assessment of Functionalized Pyridophenanthridinones via Sequential MW-Assisted Intramolecular Friedel-Crafts Alkylation and Direct C-H Arylation.Molecules (Basel, Switzerland) · 2022Article
- Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells.Investigational new drugs · 2020Article
- Study on pharmacokinetics and tissue distribution of the isocorydine derivative (AICD) in rats by HPLC-DAD method.Acta pharmaceutica Sinica. B · 2015Article
- Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C.Chemical biology & drug design · 2014Article
- Isocorydine derivatives and their anticancer activities.Molecules (Basel, Switzerland) · 2014Article
- Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids.Tetrahedron · 2013Article
- A New Route to Azafluoranthene Natural Products via Direct Arylation.European journal of organic chemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A series of synthetic aporphine derivatives structurally related to domesticine and nantenine (ring A, N6 and ring C truncated analogs), was evaluated in MTS cytotoxicity assays against the human colon cancer cell lines, HCT-116 and Caco-2. In general, the C1 position of ring A is tolerant of alkoxy substituents as well as a benzoyl ester functionality. Other modifications evaluated resulted in a decrease in cytotoxic activity. The most potent compounds identified had IC(50) values in the range 23-38 μM, comparable to the known cytotoxic agent, etoposide.
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Registered trials
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