Evidence map›Paper›PMID 21723919›Full record

ReviewNeuroscience2011

Pathological basal ganglia activity in movement disorders.

T Wichmann, J O Dostrovsky

Abstract readReview
In one paragraph

Review in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Local Field Potentials in Movement Disorders: A Narrative Review.Stereotactic and functional neurosurgery · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  18. Review
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

T WichmannYerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. twichma@emory.edu
J O Dostrovsky
Emory University · USUniversity of Toronto · CA

Funding

YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Udall Parkinson's Disease Center at Emory University: Circuitry to TherapyP50NS071669 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2010 to 2015
$6.8M
Extrastriatal functions of dopamineR01NS071074 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2010 to 2014
$1.9M
Local field potentials in the basal gangliaR01NS054976 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2006 to 2010
$1.7M
Thalamostriatal System in ParkinsonismR01NS062876 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2009 to 2011
$1.0M
MECHANISMS OF DEEP BRAIN STIMULATION.R01NS040872 · NINDS · UNIVERSITY OF TORONTO · PI DOSTROVSKY, JONATHAN O · 2001 to 2003
$258k
CIHR MOP-42505CIHR MOP-98006NCRR NIH HHS P51 RR000165NCRR NIH HHS RR-000165NINDS NIH HHS P50 NS071669NINDS NIH HHS P50-NS071669NINDS NIH HHS R01 NS054976NINDS NIH HHS R01-NS054976NINDS NIH HHS R01 NS062876NINDS NIH HHS R01 NS071074NINDS NIH HHS R01-NS071074NINDS NIH HHS R01-NS40872
6 · The paper itself

Abstract

Our understanding of the pathophysiology of movement disorders and associated changes in basal ganglia activities has significantly changed during the last few decades. This process began with the development of detailed anatomical models of the basal ganglia, followed by studies of basal ganglia activity patterns in animal models of common movement disorders and electrophysiological recordings in movement disorder patients undergoing functional neurosurgical procedures. These investigations first resulted in an appreciation of global activity changes in the basal ganglia in parkinsonism and other disorders, and later in the detailed description of pathological basal ganglia activity patterns, specifically burst patterns and oscillatory synchronous discharge of basal ganglia neurons. In this review, we critically summarize our current knowledge of the pathological discharge patterns of basal ganglia neurons in Parkinson's disease, dystonia, and dyskinesias.

Indexed as

Action PotentialsAnimalsBasal GangliaDisease Models, AnimalHumansMovement DisordersNeural PathwaysNeurons

Identifiers

PMID21723919
PMCPMC3209553
OpenAlexW1999127620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.