ArticleNeuroscience2011
Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Model-based design of subthalamic nucleus neurons using hybrid optimization.Journal of neurophysiology · 2026Article
- Article
- Modeling characteristics of neuronal firing in the thalamocortical network of connections in control and parkinsonian primates.Journal of computational neuroscience · 2025Article
- Optimization of an anatomically and electrically detailed rodent subthalamic nucleus neuron model.Journal of neurophysiology · 2024Article
- Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinson's Disease patients.Frontiers in human neuroscience · 2023Article
- Modeling the pathophysiology of Parkinson's disease in patient-specific neurons.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Endocannabinoids and Dopamine Balance Basal Ganglia Output.Frontiers in cellular neuroscience · 2021Article
- Cortical Control of Subthalamic Neuronal Activity through the Hyperdirect and Indirect Pathways in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Phase-Dependent Suppression of Beta Oscillations in Parkinson's Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate.Journal of neuroscience research · 2018Article
- Neuronal inhibition and synaptic plasticity of basal ganglia neurons in Parkinson's disease.Brain : a journal of neurology · 2018Article
- Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations.Cell reports · 2017Article
- Hyperbolic Modeling of Subthalamic Nucleus Cells to Investigate the Effect of Dopamine Depletion.Computational intelligence and neuroscience · 2017Article
- Implantable microcoils for intracortical magnetic stimulation.Science advances · 2016Article
- The external globus pallidus: progress and perspectives.The European journal of neuroscience · 2016Review
- Electrode Position and Current Amplitude Modulate Impulsivity after Subthalamic Stimulation in Parkinsons Disease-A Computational Study.Frontiers in physiology · 2016Article
- Probing the Role of Medication, DBS Electrode Position, and Antidromic Activation on Impulsivity Using a Computational Model of Basal Ganglia.Frontiers in human neuroscience · 2016Article
- The Striatum and Subthalamic Nucleus as Independent and Collaborative Structures in Motor Control.Frontiers in systems neuroscience · 2016Review
- NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neurons in the subthalamic nucleus occupy a pivotal position in the circuitry of the basal ganglia. They receive direct excitatory input from the cerebral cortex and the intralaminar nuclei of the thalamus, and directly excite the inhibitory basal ganglia output neurons in the internal segment of the globus pallidus and the substantia nigra. They are also engaged in a reciprocal synaptic arrangement with inhibitory neurons in the external segment of the globus pallidus. Although once viewed as a simple relay of extrinsic input to the basal ganglia, physiological studies of subthalamic neurons have revealed that activity in these neurons does not directly reflect their pattern of extrinsic excitation. Subthalamic neurons are autonomously active at rates comparable to those observed in vivo, and they generate complex patterns of intrinsic activity arising from the interactions between voltage sensitive ion channels on the somatodendritic and axonal membranes. Extrinsic synaptic excitation does not create the firing pattern of the subthalamic neuron, but rather controls the timing of action potentials generated intrinsically. The dopaminergic innervation of the subthalamic nucleus, although moderate, can directly influence firing patterns by acting both on synaptic transmission and voltage-sensitive ion channels responsible for intrinsic properties. Furthermore, chronic dopamine depletion in Parkinson's disease may modify both synaptic transmission and integration in the subthalamic nucleus, in addition to its effects on other regions of the basal ganglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.