ReviewBiochimica et biophysica acta2011
Mannose 6-phosphate receptor homology (MRH) domain-containing lectins in the secretory pathway.
Review in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Involvement of sphingosine 1-phosphate signaling in insulin-like growth factor-II/mannose 6-phosphate receptor trafficking from endosome to the trans-Golgi network.Communications biology · 2024Article
- Identification of novel drug targets for osteoarthritis by integrating genetics and proteomes from blood.Journal of orthopaedic surgery and research · 2024Article
- Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome.Microbiome · 2021Article
- N-Glycosylation.Advances in experimental medicine and biology · 2021Article
- On the Potential Function of Type II ArabinogalactanFrontiers in plant science · 2020Review
- Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate.Molecular and cellular biology · 2018Article
- Processing of the Terminal Alpha-1,2-Linked Mannose Residues From OligomannosidicFrontiers in plant science · 2018Article
- Biological roles of glycans.Glycobiology · 2017Review
- Multiple Domains of GlcNAc-1-phosphotransferase Mediate Recognition of Lysosomal Enzymes.The Journal of biological chemistry · 2016Article
- Article
- Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor.Glycobiology · 2015Article
- Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization.Traffic (Copenhagen, Denmark) · 2015Article
- Glucosidase II and MRH-domain containing proteins in the secretory pathway.Current protein & peptide science · 2015Review
- Convergent and divergent mechanisms of sugar recognition across kingdoms.Current opinion in structural biology · 2014Review
- Structure of the lectin mannose 6-phosphate receptor homology (MRH) domain of glucosidase II, an enzyme that regulates glycoprotein folding quality control in the endoplasmic reticulum.The Journal of biological chemistry · 2013Article
- Insulin in the brain: there and back again.Pharmacology & therapeutics · 2012Review
- The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates.Glycobiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe mannose 6-phosphate receptor homology (MRH) domain-containing family of proteins, which include recycling receptors (mannose 6-phosphate receptors, MPRs), resident endoplasmic reticulum (ER) proteins (glucosidase II β-subunit, XTP3-B, OS-9), and a Golgi glycosyltransferase (GlcNAc-phosphotransferase γ-subunit), are characterized by the presence of one or more MRH domains. Many MRH domains act as lectins and bind specific phosphorylated (MPRs) or non-phosphorylated (glucosidase II β-subunit, XTP3-B and OS-9) high mannose-type N-glycans. The MPRs are the only proteins known to bind mannose 6-phosphate (Man-6-P) residues via their MRH domains. SCOPE OF REVIEW: Recent biochemical and structural studies that have provided valuable insight into the glycan specificity and mechanisms of carbohydrate recognition by this diverse group of MRH domain-containing proteins are highlighted. MAJOR
conclusionsCurrently, three-dimensional structures are known for ten MRH domains, revealing the conservation of a similar fold. OS-9 and the MPRs use the same four residues (Gln, Arg, Glu, and Tyr) to bind mannose. GENERAL SIGNIFICANCE: The MRH domain-containing proteins play key roles in the secretory pathway: glucosidase II, XTP3-B, and OS-9 are involved in the recognition of nascent glycoproteins, whereas the MPRs play an essential role in lysosome biogenesis by targeting Man-6-P-containing lysosomal enzymes to the lysosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.