ArticleInternational journal for parasitology2011
Mining the Giardia genome and proteome for conserved and unique basal body proteins.
Article in International journal for parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The cytoskeleton of pathogenic protists.Bioscience reports · 2026Review
- Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia.MicrobiologyOpen · 2025Article
- Identification and confirmation of SUMOylation-modified proteins in Giardia trophozoites.Parasites, hosts and diseases · 2025Article
- CilioGenics: an integrated method and database for predicting novel ciliary genes.Nucleic acids research · 2024Article
- Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium.Journal of developmental biology · 2023Article
- Application of Proteomics to the Study of the Therapeutics and Pathogenicity ofDiagnostics (Basel, Switzerland) · 2022Review
- Article
- Applied Proteomics in 'One Health'.Proteomes · 2021Review
- A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia.Parasites & vectors · 2021Article
- Giardia intestinalis coiled-coil cytolinker protein 259 interacts with actin and tubulin.Parasitology research · 2021Article
- Disc-associated proteins mediate the unusual hyperstability of the ventral disc inJournal of cell science · 2020Article
- Microtubule organelles in Giardia.Advances in parasitology · 2020Review
- Roles of end-binding 1 protein and gamma-tubulin small complex in cytokinesis and flagella formation of Giardia lamblia.MicrobiologyOpen · 2019Article
- Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia.Infection and immunity · 2019Article
- In silico analysis of the EF-hand proteins in the genome of Giardia intestinalis assembly A.Parasitology research · 2018Article
- 'Disc-o-Fever': Getting Down with Giardia's Groovy Microtubule Organelle.Trends in cell biology · 2018Review
- Article
- Identification of a Novel Microtubule-Binding Protein in Giardia lamblia.The Korean journal of parasitology · 2016Article
- Induction of virulence factors in Giardia duodenalis independent of host attachment.Scientific reports · 2016Article
- Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Giardia lamblia is a flagellated protozoan parasite and a major cause of diarrhoea in humans. Its microtubular cytoskeleton mediates trophozoite motility, attachment and cytokinesis, and is characterised by an attachment disk and eight flagella that are each nucleated in a basal body. To date, only 10 giardial basal body proteins have been identified, including universal signalling proteins that are important for regulating mitosis or differentiation. In this study, we have exploited bioinformatics and proteomic approaches to identify new Giardia basal body proteins and confocal microscopy to confirm their localisation in interphase trophozoites. This approach identified 75 homologs of conserved basal body proteins in the genome including 65 not previously known to be associated with Giardia basal bodies. Thirteen proteins were confirmed to co-localise with centrin to the Giardia basal bodies. We also demonstrate that most basal body proteins localise to additional cytoskeletal structures in interphase trophozoites. This might help to explain the roles of the four pairs of flagella and Giardia-specific organelles in motility and differentiation. A deeper understanding of the composition of the Giardia basal bodies will contribute insights into the complex signalling pathways that regulate its unique cytoskeleton and the biological divergence of these conserved organelles.
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Registered trials
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