ArticleHeart rhythm2011
Left-to-right ventricular differences in I(KATP) underlie epicardial repolarization gradient during global ischemia.
Article in Heart rhythm, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Ventricular fibrillation dynamics reveal regional asymmetry in resilience to cardiac arrest and predict clinical outcome.Cardiovascular research · 2026Article
- Origin of ventricular fibrillation triggers in a model of localized repolarization heterogeneity.Heart rhythm · 2025Article
- Cardiac electro-mechanical activity in a deforming human cardiac tissue: modeling, existence-uniqueness, finite element computation and application to multiple ischemic disease.Journal of mathematical biology · 2022Article
- Exploring Functional Differences between the Right and Left Ventricles to Better Understand Right Ventricular Dysfunction.Oxidative medicine and cellular longevity · 2021Review
- Dispersion of ventricular repolarization: Temporal and spatial.World journal of cardiology · 2020Review
- Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits KLipids in health and disease · 2020Article
- Contribution of Depolarization and Repolarization Changes to J-Wave Generation and Ventricular Fibrillation in Ischemia.Frontiers in physiology · 2020Article
- Modeling and simulation of cardiac electric activity in a human cardiac tissue with multiple ischemic zones.Journal of mathematical biology · 2019Article
- Global Bi-ventricular endocardial distribution of activation rate during long duration ventricular fibrillation in normal and heart failure canines.BMC cardiovascular disorders · 2017Article
- Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis.Arrhythmia & electrophysiology review · 2016Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Interventricular differences in β-adrenergic responses in the canine heart: role of phosphodiesterases.Journal of the American Heart Association · 2014Article
- Reduced Na⁺ current density underlies impaired propagation in the diabetic rabbit ventricle.Journal of molecular and cellular cardiology · 2014Article
- Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: mechanistic insights from rabbit ventricular models.Heart rhythm · 2013Article
- Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels.Molecular pharmacology · 2012Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe ionic mechanisms of electrical heterogeneity in the ischemic ventricular epicardium remain poorly understood.
objectiveThis study sought to test the hypothesis that the adenosine triphosphate (ATP)-activated K+ current (I(KATP)) plays an important role in mediating repolarization differences between the right ventricle (RV) and left ventricle (LV) during global ischemia.
methodsElectrical activity in Langendorff-perfused guinea pig hearts was recorded optically during control, ischemia, and reperfusion. Patch-clamp experiments were used to quantify I(KATP) density in isolated myocytes. Molecular correlates of I(KATP) (Kir6/SUR) were probed via reverse transcriptase-polymerase chain reaction. The role of I(KATP) in modulating repolarization was studied using computer simulations.
resultsAction potential duration (APD) was similar between LV and RV in control hearts, but significantly different in global ischemia. Pretreatment of hearts with 10 μM glibenclamide (I(KATP) blocker) abolished the APD gradient during ischemia. In the absence of ischemia, pinacidil (I(KATP) opener) tended to shorten the APD more in the LV, and caused a small but significant increase in APD dispersion. In voltage clamp experiments, the density of the whole-cell current activated by pinacidil at depolarized potentials was significantly larger in LV, compared with RV epicardial myocytes. The mRNA levels of Kir6.1/Kir6.2 were significantly higher in LV compared with RV. Simulations showed that I(KATP) is the main determinant of LV-RV APD gradient, whereas cell-to-cell coupling modified the spatial distribution of this APD gradient.
conclusionI(KATP) is an important determinant of the epicardial LV-RV APD gradient during global ischemia, in part due to a higher current density and molecular expression in the LV.
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Registered trials
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