ArticleBiophysical journal2011
Cytoplasmic domain filter function in the mechanosensitive channel of small conductance.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Roles of Bacterial Mechanosensitive Channels in Infection and Antibiotic Susceptibility.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Decisive structural elements in water and ion permeation through mechanosensitive channels of large conductance: insights from molecular dynamics simulation.RSC advances · 2022Article
- Nonpolar residues in the presumptive pore-lining helix of mechanosensitive channel MSL10 influence channel behavior and establish a nonconducting function.Plant direct · 2018Article
- Transmembrane TM3b of Mechanosensitive Channel MscS Interacts With Cytoplasmic Domain Cyto-Helix.Frontiers in physiology · 2018Article
- Identification of Intracellular β-Barrel Residues Involved in Ion Selectivity in the Mechanosensitive Channel ofFrontiers in physiology · 2017Article
- Arabidopsis MSL10 has a regulated cell death signaling activity that is separable from its mechanosensitive ion channel activity.The Plant cell · 2014Article
- Selectivity mechanisms in MscS-like channels: From structure to function.Channels (Austin, Tex.) · 2014Article
- Energetics of gating MscS by membrane tension in azolectin liposomes and giant spheroplasts.Channels (Austin, Tex.) · 2014Article
- Exploring the pH-dependent substrate transport mechanism of FocA using molecular dynamics simulation.Biophysical journal · 2013Article
- A computational kinetic model of diffusion for molecular systems.The Journal of chemical physics · 2013Article
- MscS-like mechanosensitive channels in plants and microbes.Biochemistry · 2013Review
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Recent characterizations of MscS and its homologs provide insight into the basis of ion selectivity in mechanosensitive channels.Channels (Austin, Tex.)Article
- Mechanical properties of lipid bilayers and regulation of mechanosensitive function: from biological to biomimetic channels.Channels (Austin, Tex.)Review
- Characterization of three novel mechanosensitive channel activities in Escherichia coli.Channels (Austin, Tex.)Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Mechanosensitive channels, inner membrane proteins of bacteria, open and close in response to mechanical stimuli such as changes in membrane tension during osmotic stress. In bacteria, these channels act as safety valves preventing cell lysis upon hypoosmotic cell swelling: the channels open under membrane tension to release osmolytes along with water. The mechanosensitive channel of small conductance, MscS, consists, in addition to the transmembrane channel, of a large cytoplasmic domain (CD) that features a balloon-like, water filled chamber opening to the cytoplasm through seven side pores and a small distal pore. The CD is apparently a molecular sieve covering the channel that optimizes loss of osmolytes during osmoadaptation. We employ diffusion theory and molecular dynamics simulations to explore the transport kinetics of Glu(-) and K(+) as representative osmolytes. We suggest that the CD indeed acts as a filter that actually balances passage of Glu(-) and K(+), and possibly other positive and negative osmolytes, to yield a largely neutral efflux and, thereby, reduce cell depolarization in the open state and conserve to a large degree the essential metabolite Glu(-).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.