ArticleBiophysical journal2011
Origins and consequences of velocity fluctuations during DNA passage through a nanopore.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Microfluidic Sample Compartmentalization for Biomolecular Concentration Quantification Using a Nanopore Sensor.Small methods · 2026Article
- Metrology of Nanoscale Objects Using Nanopores.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Nanopore assay for fingerprinting DNA binding and quantifying real-time cleavage by catalytically active Cas9 enzyme.Journal of nanobiotechnology · 2025Article
- Brownian motion data augmentation: a method to push neural network performance on nanopore sensors.Bioinformatics (Oxford, England) · 2025Article
- Crowding Effects during DNA Translocation in Nanopipettes.ACS nano · 2025Article
- Charge symmetry breaking in neutral polyzwitterions.Nature communications · 2025Article
- DNA Barcodes Using a Dual Nanopore Device.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing.Clinical epigenetics · 2022Review
- Electronic Mapping of a Bacterial Genome with Dual Solid-State Nanopores and Active Single-Molecule Control.ACS nano · 2022Article
- Detection and Characterization of Single Cisplatin Adducts on DNA by Nanopore Sequencing.ACS omega · 2021Article
- DNA barcode by flossing through a cylindrical nanopore.RSC advances · 2021Article
- Translocation of DNA through Ultrathin Nanoslits.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Solid-state nanopores towards single-molecule DNA sequencing.Journal of human genetics · 2020Review
- Complex DNA knots detected with a nanopore sensor.Nature communications · 2019Article
- High bandwidth approaches in nanopore and ion channel recordings - A tutorial review.Analytica chimica acta · 2019Review
- Wavelet Denoising of High-Bandwidth Nanopore and Ion-Channel Signals.Nano letters · 2019Article
- Characterization of Virus Capsids and Their Assembly Intermediates by Multicycle Resistive-Pulse Sensing with Four Pores in Series.Analytical chemistry · 2018Article
- Real-Time Nanopore-Based Recognition of Protein Translocation Success.Biophysical journal · 2018Article
- DNA Translocations through Nanopores under Nanoscale Preconfinement.Nano letters · 2018Article
- Ionic Current-Based Mapping of Short Sequence Motifs in Single DNA Molecules Using Solid-State Nanopores.Nano letters · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We describe experiments and modeling results that reveal and explain the distribution of times that identical double-stranded DNA (dsDNA) molecules take to pass through a voltage-biased solid-state nanopore. We show that the observed spread in this distribution is caused by viscous-drag-induced velocity fluctuations that are correlated with the initial conformation of nanopore-captured molecules. This contribution exceeds that due to diffusional Brownian motion during the passage. Nevertheless, and somewhat counterintuitively, the diffusional Brownian motion determines the fundamental limitations of rapid DNA strand sequencing with a nanopore. We model both diffusional and conformational fluctuations in a Langevin description. It accounts well for passage time variations for DNA molecules of different lengths, and predicts conditions required for low-error-rate nanopore-strand DNA sequencing with nanopores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.