ArticleCell metabolism2011
Islets have a lot of nerve! Or do they?
Article in Cell metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.Cell metabolism · 2020Trial
- The nerve center of organ engineering.Nature communications · 2025Review
- Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells.Diabetes · 2025Article
- A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization's Role as a Treatment Modality.International journal of molecular sciences · 2023Review
- The past, present, and future physiology and pharmacology of glucagon.Cell metabolism · 2022Review
- Phosphoproteome reveals molecular mechanisms of aberrant rhythm in neurotransmitter-mediated islet hormone secretion in diabetic mice.Clinical and translational medicine · 2022Article
- Pancreatic β-Cells Communicate With Vagal Sensory Neurons.Gastroenterology · 2021Article
- DIlp7-Producing Neurons Regulate Insulin-Producing Cells inFrontiers in physiology · 2021Article
- Recruited fibroblasts reconstitute the peri-islet membrane: a longitudinal imaging study of human islet grafting and revascularisation.Diabetologia · 2020Article
- Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion.Frontiers in neuroscience · 2019Review
- Review
- The Role of Accessory Cells in Islet Homeostasis.Current diabetes reports · 2018Review
- Article
- Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.Scientific reports · 2017Article
- The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.Diabetes · 2016Article
- Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves.Diabetes · 2016Article
- Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.Nature neuroscience · 2014Article
- Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation.Cell reports · 2013Article
- 3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury.Diabetologia · 2012Article
- Central nervous system control of metabolism.Nature · 2012Review
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
The autonomic nervous system influences insulin and glucagon secretion. In this issue, Rodriguez-Diaz et al. (2011) show that mouse and human islets differ in their innervation patterns, yet the effect of neural activation on islet hormone secretion is similar. Key questions raised by this species difference have potential relevance to diabetic therapeutics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.