ArticleBone2011
Knee loading stimulates healing of mouse bone wounds in a femur neck.
Article in Bone, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Mechanical Loading Promotes the Migration of Endogenous Stem Cells and Chondrogenic Differentiation in a Mouse Model of Osteoarthritis.Calcified tissue international · 2023Article
- Mechanical loading stimulates bone angiogenesis through enhancing type H vessel formation and downregulating exosomal miR-214-3p from bone marrow-derived mesenchymal stem cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Mechanical stimulations can inhibit local and remote tumor progression by downregulating WISP1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Finite-element analysis of the mouse proximal ulna in response to elbow loading.Journal of bone and mineral metabolism · 2019Article
- Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Effects of knee loading on obesity-related non-alcoholic fatty liver disease in an ovariectomized mouse model with high-fat diet.Hepatology research : the official journal of the Japan Society of Hepatology · 2018Article
- Development of an Artificial Finger-Like Knee Loading Device to Promote Bone Health.Journal of biomedical science and engineering · 2017Article
- A Mechatronic Loading Device to Stimulate Bone Growth via a Human Knee.Sensors (Basel, Switzerland) · 2016Article
- Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.Scientific reports · 2016Article
- Article
- Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem.PloS one · 2014Article
- Knee loading reduces MMP13 activity in the mouse cartilage.BMC musculoskeletal disorders · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Healing of bone wounds is sensitive to various environmental stimuli. Using knee loading, which has been shown to stimulate bone formation in mouse femora and tibiae, we addressed a question: Does knee loading accelerate a closure of open wounds in a femur neck? A surgical wound (0.5 mm in diameter) was generated at the femur neck in the left and right femora of C57/BL/6 female mice, and knee loading was applied to the left knee for 3 min/day for 3 consecutive days. Surgical holes at the femoral midshaft were used as control. Animals were sacrificed 1, 2, and 3 weeks after surgery for analyses with μCT and pQCT as well as mechanical testing. The results showed load-driven acceleration of the closure of surgical holes. Compared to a sham-loaded contralateral control, knee loading reduced the size of surgical wounds in the femoral midshaft by 14% (p<0.05), 21% (p<0.01), and 32% (p<0.001) in 1, 2, and 3 weeks, respectively. It also decreased the wound size in the femur neck by 16% (p<0.001; 1 week), 18% (p<0.001; 2 weeks), and 21% (p<0.001; 3 weeks). Images with pQCT revealed that bone mineral density (BMD) was increased from 571±19 mg/cm(3) (control) to 686±19 mg/cm(3) (loaded) (p<0.01), and bone mineral content (BMC) from 3.05±0.12 mg/mm (control) to 3.42±0.11 mg/mm (loaded) (p<0.05). Furthermore, mechanical testing showed that stiffness of the femur was increased by knee loading (p<0.05). This study demonstrates that knee loading is capable of accelerating healing of surgical wounds throughout the femur including the femoral midshaft and neck.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.