ArticlePhysiology & behavior2011
Estradiol suppresses recovery of REM sleep following sleep deprivation in ovariectomized female rats.
Article in Physiology & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- The median preoptic nucleus is a key site for estradiol regulation of sleep-wake behaviors in females rats.Sleep · 2026Article
- Correlation study of polysomnographic parameters, serological markers, and gut microbiota in patients with short-sleep insomnia: a real-world study.Frontiers in microbiology · 2026Article
- The Median Preoptic Nucleus is a Key Site for Estradiol Regulation of Sleep-Wake Behaviors in Females Rats.bioRxiv : the preprint server for biology · 2025Article
- Article
- On the basis of sex and sleep: the influence of the estrous cycle and sex on sleep-wake behavior.Frontiers in neuroscience · 2024Review
- Estradiol influences adenosinergic signaling and nonrapid eye movement sleep need in adult female rats.Sleep · 2022Article
- Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan.Endocrinology · 2020Review
- Age of puberty and Sleep duration: Observational and Mendelian randomization study.Scientific reports · 2020Observational
- Sex- and Age-dependent Differences in Sleep-wake Characteristics of Fisher-344 Rats.Neuroscience · 2020Article
- Noise-induced sleep disruption increases weight gain and decreases energy metabolism in female rats.International journal of obesity (2005) · 2019Article
- The Role of Estrogen in Brain and Cognitive Aging.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Acute Kynurenine Challenge Disrupts Sleep-Wake Architecture and Impairs Contextual Memory in Adult Rats.Sleep · 2017Article
- Ovarian hormones, sleep and cognition across the adult female lifespan: An integrated perspective.Frontiers in neuroendocrinology · 2017Review
- Sex differences in sleep: impact of biological sex and sex steroids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The Neurobiology of Sleep and Wakefulness.The Psychiatric clinics of North America · 2015Review
- In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.Sleep · 2014Article
- Gonadal steroid modulation of sleep and wakefulness in male and female rats is sexually differentiated and neonatally organized by steroid exposure.Endocrinology · 2014Article
- Article
- Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Sex chromosomes regulate nighttime sleep propensity during recovery from sleep loss in mice.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sleep complaints such as insufficient sleep and insomnia are twice as prevalent in women. Symptoms of sleep disruption are often coincident with changes in the gonadal hormone profile across a women's lifespan. Data from a number of different species, including humans, non-human primates and rodents strongly implicate a role for gonadal hormones in the modulation of sleep. In female rats, increased levels of circulating estradiol increase wakefulness and reduce sleep in the dark phase. In this study, we asked whether this reduction in sleep is driven by estradiol-dependent reduction in sleep need during the dark phase by assessing sleep before and after sleep deprivation (SD). Ovariectomized rats implanted with EEG telemetry transmitters were given Silastic capsules containing either 17-β estradiol in sesame oil (E2) or sesame oil alone. After a 24-hour baseline, animals were sleep-deprived via gentle handling for the entire 12-hour light phase, and then allowed to recover. E2 treatment suppressed baseline REM sleep duration in the dark phase, but not NREM or Wake duration, within three days. While SD induced a compensatory increase in REM duration in both groups, this increase was smaller in E2-treated rats compared to oils, as measured in absolute duration as well as by relative increase over baseline. Thus, E2 suppressed REM sleep in the dark phase both before and after SD. E2 also suppressed NREM and increased waking in the early- to mid-dark phase on the day after SD. NREM delta power tracked NREM sleep before and after SD, with small hormone-dependent reductions in delta power in recovery, but not spontaneous sleep. These results demonstrate that E2 powerfully and specifically suppresses spontaneous and recovery REM sleep in the dark phase, and suggest that ovarian steroids may consolidate circadian sleep-wake rhythms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.