ArticleThe Journal of cell biology1990
Regulation of organelle transport in melanophores by calcineurin.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 75 citations in OpenAlex.
- High-intensity light disrupts intracellular organelle dynamics via microtubule depolymerization.Scientific reports · 2025Article
- From extraocular photoreception to pigment movement regulation: a new control mechanism of the lanternshark luminescence.Scientific reports · 2020Article
- Carbachol-mediated pigment granule dispersion in retinal pigment epithelium requires Ca2+ and calcineurin.BMC cell biology · 2007Article
- Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill.BMC neuroscience · 2004Article
- Dynein, dynactin, and kinesin II's interaction with microtubules is regulated during bidirectional organelle transport.The Journal of cell biology · 2000Article
- Regulation of organelle movement in melanophores by protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2A (PP2A).The Journal of cell biology · 1998Article
- Regulated bidirectional motility of melanophore pigment granules along microtubules in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cell cycle regulation of dynein association with membranes modulates microtubule-based organelle transport.The Journal of cell biology · 1996Article
- Protein phosphatase 1 regulates the cytoplasmic dynein-driven formation of endoplasmic reticulum networks in vitro.The Journal of cell biology · 1995Article
- Differential phosphorylation in vivo of cytoplasmic dynein associated with anterogradely moving organelles.The Journal of cell biology · 1994Article
- Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.The Journal of cell biology · 1994Article
- Intracellular calcium and cAMP regulate directional pigment movements in teleost erythrophores.The Journal of cell biology · 1994Article
- Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity.Molecular biology of the cell · 1993Article
- GTP gamma S inhibits organelle transport along axonal microtubules.The Journal of cell biology · 1993Article
- Protein kinase C activation antagonizes melatonin-induced pigment aggregation in Xenopus laevis melanophores.The Journal of cell biology · 1992Article
- Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.Molecular and cellular biology · 1992Article
- Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging.The Journal of cell biology · 1992Article
- Two activators of microtubule-based vesicle transport.The Journal of cell biology · 1991Article
- Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that pigment granule dispersion and aggregation in melanophores of the African cichlid, Tilapia mossambica, are regulated by protein phosphorylation and dephosphorylation, respectively (Rozdzial, M. M., and L. T. Haimo. 1986. Cell. 47:1061-1070). The present studies suggest that calcineurin, a Ca2+/calmodulin-stimulated phosphatase, is the endogenous phosphatase that mediates pigment aggregation in melanophores. Aggregation, but not dispersion, is inhibited by okadaic acid at concentrations consistent with an inhibition of calcineurin activity. Inhibition of aggregation in melanophores that have been BAPTA loaded or treated with calmodulin antagonists implicate Ca2+ and calmodulin, respectively, in this process. Moreover, addition of calcineurin rescues aggregation in lysed melanophores which are otherwise incapable of aggregating pigment. Immunoblotting with an anticalcineurin IgG reveals that calcineurin is a component of the dermis, which contains the melanophores, and indirect immunofluorescence localizes calcineurin specifically to the melanophores. Finally, this antibody, which inhibits calcineurin's phosphatase activity (Tash, J. S., M. Krinks, J. Patel, R. L. Means, C. B. Klee, and A. R. Means. 1988. J. Cell Biol. 106:1625-1633), inhibits aggregation but has no effect on pigment granule dispersion. Together these studies indicate that retrograde transport of pigment granules to the melanophore cell center depends upon the participation of calcineurin.
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