Trial reportJournal of diabetes science and technology2011
The effect of type-2-diabetes-related vascular endothelial dysfunction on skin physiology and activities of daily living.
Trial report in Journal of diabetes science and technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Urban heat island impacts on heat-related cardiovascular morbidity: A time series analysis of older adults in US metropolitan areas.Environment international · 2023Pooled it
- Reactive Hyperemia and Cardiovascular Autonomic Neuropathy in Type 2 Diabetic Patients: A Systematic Review of Randomized and Nonrandomized Clinical Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Impact of daily cooling treatment on skin inflammation in patients with chronic venous disease.Journal of tissue viability · 2015Trial
- The effect of acute administration of vitamin D on micro vascular endothelial function in Caucasians and South Asian Indians.Medical science monitor : international medical journal of experimental and clinical research · 2013Trial
- CoQ10 and endothelial function in Asians from Korea compared to Asians born in the United States and US born Caucasians.Medical science monitor : international medical journal of experimental and clinical research · 2013Trial
- The effect of increased core body temperature on the vasomotor and sudomotor responses of patients with type 2 diabetes: protocol of a systematic literature review and meta-analysis.Systematic reviews · 2025Article
- Short-term exposure to ambient temperature variability and myocardial infarction hospital admissions: A nationwide case-crossover study in Sweden.PLoS medicine · 2025Article
- Blunted cardiovascular responses in individuals with type 2 diabetes and hypertension during cold and heat exposure.Frontiers in physiology · 2025Article
- Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration.Environment international · 2023Article
- A novel, microvascular evaluation method and device for early diagnosis of peripheral artery disease and chronic limb-threatening ischemia in individuals with diabetes.Journal of vascular surgery cases and innovative techniques · 2023Article
- Functional near infrared spectroscopy detects cortical activation changes concurrent with memory loss in postmenopausal women with Type II Diabetes.Experimental brain research · 2023Article
- Mediation effect of the duration of diabetes mellitus on the decrease in bioimpedance phase angles in ethnically Korean people: A multicenter clinical study.Journal of diabetes investigation · 2021Observational
- Hemodynamic Function of Forearm Muscle in Postmenopausal Women With Type 2 Diabetes.Journal of aging and physical activity · 2020Article
- Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes.Neurophotonics · 2020Article
- Type 2 diabetes does not exacerbate body heat storage in older adults during brief, extreme passive heat exposure.Temperature (Austin, Tex.) · 2020Article
- Short-term association between ambient temperature and acute myocardial infarction hospitalizations for diabetes mellitus patients: A time series study.PLoS medicine · 2018Article
- The Effects of Chronic Aerobic Exercise on Cardiovascular Risk Factors in Persons with Diabetes Mellitus.Current diabetes reports · 2017Review
- Coefficient of Friction at the Fingertips in Type II Diabetics Compared to Healthy Adults.Journal of applied biomechanics · 2017Article
- Protective effect of Xin Mai Jia ultrafiltration extract on human umbilical vein endothelial cell injury induced by hydrogen peroxide and the effect on the NO-cGMP signaling pathway.Experimental and therapeutic medicine · 2014Article
- Detecting subtle fingertip sensory and motor dysfunction in adults with type II diabetes.Experimental brain research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A common factor contributing to organ damage in type 2 diabetes mellitus (T2DM) is impaired tissue blood flow caused by damage to vascular endothelial cells (VECs). Damage can occur even before the clinical diagnosis of diabetes. It can be caused by both a high average blood glucose concentration and/or large daily spikes in blood glucose. While much of the present literature focuses on the damage to VECs and organs from these large glucose excursions, this review will focus on the consequence of this damage, that is, how endothelial cell damage in diabetes affects normal daily activities (e.g., exercise, reaction to typical stimuli) and various treatment modalities (e.g.. contrast baths and electrical stimulation therapy). It is important to understand the effects of VEC damage such as poor skin blood flow, compromised thermoregulation, and altered response to skin pressure in designing diabetes technologies as simple as heating pads and as complex as continuous glucose monitors. At the simplest level, people with diabetes have poor circulation to the skin and other organs. In the skin, even the blood flow response to locally applied pressure, such as during standing, is different than for people who do not have T2DM. Simple weight bearing on the foot can occlude the skin circulation. This makes the skin more susceptible to damage. In addition, endothelial damage has far-reaching effects on the whole body during normal activities of daily living, including an impaired response to local heat, such as hot packs and contrast baths, and higher body temperatures during whole body heating due to impaired blood flow and a reduced ability to sweat. Finally, because of multiple organ damage, people with T2DM have poor balance and gait and impaired exercise performance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.