ArticleJournal of diabetes science and technology2011
Modulation of the foreign body reaction for implants in the subcutaneous space: microdialysis probes as localized drug delivery/sampling devices.
Article in Journal of diabetes science and technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Dynamic and living devices for overcoming fibrosis of implanted biomaterials.Bioengineering & translational medicine · 2026Review
- Iloprost Affects Macrophage Activation and CCL2 Concentrations in a Microdialysis Model in Rats.Pharmaceutical research · 2018Article
- Drug delivery strategies to control macrophages for tissue repair and regeneration.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue.The Analyst · 2015Review
- Localized delivery of dexamethasone-21-phosphate via microdialysis implants in rat induces M(GC) macrophage polarization and alters CCL2 concentrations.Acta biomaterialia · 2015Article
- Microdialysis sampling techniques applied to studies of the foreign body reaction.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2014Review
- Comparison of microdialysis sampling perfusion fluid components on the foreign body reaction in rat subcutaneous tissue.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2014Article
- Pharmacological mitigation of tissue damage during brain microdialysis.Analytical chemistry · 2013Article
- Biocompatible materials for continuous glucose monitoring devices.Chemical reviews · 2013Review
- Microdialysis probes alter presynaptic regulation of dopamine terminals in rat striatum.Journal of neuroscience methods · 2012Article
- Effect of dexamethasone on gliosis, ischemia, and dopamine extraction during microdialysis sampling in brain tissue.Analytical chemistry · 2011Article
- Interstitial fluid physiology as it relates to glucose monitoring technologies: symposium introduction.Journal of diabetes science and technology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Modulation of the foreign body reaction is considered to be an important step toward creation of implanted sensors with reliable long-term performance. In this work, microdialysis probes were implanted into the subcutaneous space of Sprague-Dawley rats. The probe performance was evaluated by comparing collected endogenous glucose concentrations with internal standard calibration (2-deoxyglucose, antipyrine, and vitamin B12). Probes were tested until failure, which for this work was defined as loss of fluid flow. In order to determine the effect of fibrous capsule formation on probe function, monocyte chemoattractant protein-1/CC chemokine ligand 2 (MCP-1/CCL2) was delivered locally via the probe to increase capsule thickness and dexamethasone 21-phosphate was delivered to reduce capsule thickness. Probes delivering MCP-1 had a capsule that was twice the thickness (500-600 μm) of control probes (200-225 μm) and typically failed 2 days earlier than control probes. Probes delivering dexamethasone 21-phosphate had more fragile capsules and the probes typically failed 2 days later than controls. Unexpectedly, extraction efficiency and collected glucose concentrations exhibited minor differences between groups. This is an interesting result in that the foreign body capsule formation was related to the duration of probe function but did not consistently relate to probe calibration.
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Registered trials
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