ReviewCritical care (London, England)2011
Supplementary oxygen for nonhypoxemic patients: O2 much of a good thing?
Review in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients (SAVE-O2)
Strategy to Avoid Excessive Oxygen in Major Burn Patients (SAVE-O2)
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials.Journal of cardiothoracic surgery · 2021Pooled it
- Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2014Pooled it
- Effect of Oxygen vs Room Air on Intrauterine Fetal Resuscitation: A Randomized Noninferiority Clinical Trial.JAMA pediatrics · 2018Trial
- Effects of modest hyperoxia and oral vitamin C on exercise hyperaemia and reactive hyperaemia in healthy young men.European journal of applied physiology · 2015Trial
- The Predictive Utility of Arterial Blood Gas Analysis for ICU Transfer and In-Hospital Mortality Among General Internal Medicine Inpatients.International journal of general medicine · 2026Article
- Maternal oxygen inhalation affects the fetal hemodynamic in low-risk with uncomplicated late pregnancy.European journal of medical research · 2025Article
- Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.Magnetic resonance imaging · 2023Article
- "Nitrogen Wash-Out" in Non-Hypoxaemic Patients with Spontaneous Pneumothorax: A Narrative Review.Journal of clinical medicine · 2023Review
- Hyperoxia in portal vein causes enhanced vasoconstriction in arterial vascular bed.Scientific reports · 2020Article
- Refinement of a chronic cranial window implant in the rat for longitudinal in vivo two-photon fluorescence microscopy of neurovascular function.Scientific reports · 2019Article
- Hyperoxia-induced cardiotoxicity and ventricular remodeling in type-II diabetes mice.Heart and vessels · 2018Article
- Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Does oxygen therapy increase the resolution rate of primary spontaneous pneumothorax?Journal of thoracic disease · 2017Article
- Respiratory Support for Pharmacologically Induced Hypoxia in Neonatal Calves.Veterinary medicine international · 2016Article
- Bench-to-bedside review: the effects of hyperoxia during critical illness.Critical care (London, England) · 2015Review
- Oxidation increases mucin polymer cross-links to stiffen airway mucus gels.Science translational medicine · 2015Article
- Plasma thioredoxin levels during post-cardiac arrest syndrome: relationship with severity and outcome.Critical care (London, England) · 2013Article
- Effects of 2 modes of positive pressure ventilation on respiratory mechanics and gas exchange in foals.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supplementary oxygen is routinely administered to patients, even those with adequate oxygen saturations, in the belief that it increases oxygen delivery. But oxygen delivery depends not just on arterial oxygen content but also on perfusion. It is not widely recognized that hyperoxia causes vasoconstriction, either directly or through hyperoxia-induced hypocapnia. If perfusion decreases more than arterial oxygen content increases during hyperoxia, then regional oxygen delivery decreases. This mechanism, and not (just) that attributed to reactive oxygen species, is likely to contribute to the worse outcomes in patients given high-concentration oxygen in the treatment of myocardial infarction, in postcardiac arrest, in stroke, in neonatal resuscitation and in the critically ill. The mechanism may also contribute to the increased risk of mortality in acute exacerbations of chronic obstructive pulmonary disease, in which worsening respiratory failure plays a predominant role. To avoid these effects, hyperoxia and hypocapnia should be avoided, with oxygen administered only to patients with evidence of hypoxemia and at a dose that relieves hypoxemia without causing hyperoxia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.