ArticleMolecular microbiology2011
Global analysis of phase variation in Myxococcus xanthus.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Role of DKxanthenes inJournal of microbiology and biotechnology · 2026Article
- XRE transcription factors conserved in Caulobacter and φCbK modulate adhesin development and phage production.PLoS genetics · 2023Article
- Characteristics of a lipase ArEstA with lytic activity against drug-resistant pathogen from a novel myxobacterium,Frontiers in microbiology · 2023Article
- Myxobacterial Genomics and Post-Genomics: A Review of Genome Biology, Genome Sequences and Related 'Omics Studies.Microorganisms · 2021Review
- Mutants defective in the production of encapsulin show a tan-phase-locked phenotype in Myxococcus xanthus.Journal of microbiology (Seoul, Korea) · 2019Article
- Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics.Cell chemical biology · 2018Article
- Myxobacteria: Moving, Killing, Feeding, and Surviving Together.Frontiers in microbiology · 2016Review
- Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus.BMC genomics · 2014Article
- Genetic redundancy, proximity, and functionality of lspA, the target of antibiotic TA, in the Myxococcus xanthus producer strain.Journal of bacteriology · 2014Article
- Phase variation in Myxococcus xanthus yields cells specialized for iron sequestration.PloS one · 2014Article
- Article
- MasABK proteins interact with proteins of the type IV pilin system to affect social motility of Myxococcus xanthus.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Myxococcus xanthus can vary its phenotype or 'phase' to produce colonies that contain predominantly yellow or tan cells that differ greatly in their abilities to swarm, survive and develop. Yellow variants are proficient at swarming (++) and tend to lyse in liquid during stationary phase. In contrast, tan variants are deficient in swarming (+) and persist beyond stationary phase. The phenotypes and transcriptomes of yellow and tan variants were compared with mutants affected in phase variation. Thirty-seven genes were upregulated specifically in yellow variants including those for production of the yellow pigment, DKxanthene. A mutant in DKxanthene synthesis produced non-pigmented (tan) colonies but still phase varied for swarming suggesting that pigmentation is not the cause of phase variation. Disruption of a gene encoding a HTH-Xre-like regulator, highly expressed in yellow variants, abolished pigment production and blocked the ability of cells to switch from a swarm ++ to a swarm (+) phenotype, showing that HTH-Xre regulates phase variation. Among the four genes whose expression was increased in tan variants was pkn14, which encodes a serine-threonine kinase that regulates programmed cell death in Myxococcus via the MrpC-MazF toxin-antitoxin complex. High levels of phosphorylated Pkn14 may explain why tan cells enjoy enhanced survival.
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