SynthesisThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2012
Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis.
Synthesis in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Translating the immediate effects of S-Ketamine using hippocampal subfield analysis in healthy subjects-results of a randomized controlled trial.Translational psychiatry · 2021Trial
- Brain-Derived Neurotropic FactorBioMed research international · 2017Trial
- Protocol for a multisite study on the efficacy of transcranial direct current stimulation as an adjuvant to naming and spelling therapy in the treatment of oral and written naming in individuals with primary progressive aphasia.Frontiers in human neuroscience · 2025Article
- Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder.Molecular psychiatry · 2024Review
- BDNF: New Views of an Old Player in Traumatic Brain Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder.Scientific reports · 2023Article
- Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients.Molecular psychiatry · 2022Article
- Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome.Translational psychiatry · 2021Review
- A Load to Find Clinically Useful Biomarkers for Depression.Advances in experimental medicine and biology · 2021Article
- Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination.Metallomics : integrated biometal science · 2020Article
- The mouse-equivalent of the human BDNF VAL66MET polymorphism increases dorsal hippocampal volume and does not interact with developmental ethanol exposure.Alcohol (Fayetteville, N.Y.) · 2020Article
- Negative association between left prefrontal GABA concentration and BDNF serum concentration in young adults.Heliyon · 2020Article
- TheBrain sciences · 2020Review
- A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction.Frontiers in behavioral neuroscience · 2020Article
- The brain-derived neurotrophic factor VAL68MET polymorphism modulates how developmental ethanol exposure impacts the hippocampus.Genes, brain, and behavior · 2019Article
- Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases.International journal of molecular sciences · 2018Review
- Exercise-Mediated Neurogenesis in the Hippocampus via BDNF.Frontiers in neuroscience · 2018Review
- Critical Issues inFrontiers in molecular neuroscience · 2018Review
- The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial Processing.Journal of clinical medicine · 2017Article
- Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses.Frontiers in psychiatry · 2017Review
Corrections and comments
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3 authors.
Funding
Abstract
objectivesConverging evidence suggests that the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects brain structure. Yet the majority of studies have shown no effect of this polymorphism on hippocampal volumes, perhaps due to small effect size.
methodsWe performed a meta-analysis of studies investigating the association between Val66Met BDNF polymorphism and hippocampal volumes in healthy subjects by combining standardized differences between means (SDM) from individual studies using random effect models.
resultsData from 399 healthy subjects (255 Val-BDNF homozygotes and 144 carriers of at least one Met-BDNF allele) in seven studies were meta-analysed. Both the left and right hippocampi were significantly larger in Val-BDNF homozygotes than in carriers of at least one Met-BDNF allele (SDM = 0.41, 95% Confidence Interval = 0.20; 0.62, z = 3.86, P = 0.0001; SDM = 0.41; 95% Confidence Interval = 0.20; 0.61, z = 3.81, P = 0.0001, respectively), with no evidence of publication bias.
conclusionsHealthy carriers of BDNF gene Val66Met polymorphism show bilateral hippocampal volume reduction. The effect size was small, but the same direction of effect was seen in all meta-analyzed studies. The association with the BDNF gene Val66Met polymorphism makes hippocampal volume a potential candidate for an endophenotype of disorders presenting with reduced hippocampal volumes.
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