ArticleThe American journal of Chinese medicine2011
Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice.
Article in The American journal of Chinese medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed.
- Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine.Food science & nutrition · 2026Review
- Toxicological Evaluation of the Liver and Kidneys of Rats Exposed toJournal of experimental pharmacology · 2026Article
- 90-Day Subchronic Toxicological Evaluation of a Zylaria in Sprague Dawley Rats.Journal of toxicology · 2026Article
- The therapeutic role of ginseng in promoting hippocampal neurogenesis and ameliorating cognitive function following whole brain radiotherapy in rats.Metabolic brain disease · 2025Article
- Shenhuang Granules for patients with sepsis: study protocol of a multicenter, randomized, double-blind, placebo-controlled clinical trial.Frontiers in medicine · 2025Article
- Article
- Efficacy and safety evaluation of black ginseng (Panax ginseng C.A. Mey.) extract (CJ EnerG): broad spectrum cytotoxic activity in human cancer cell lines and 28-day repeated oral toxicity study in Sprague-Dawley rats.BMC complementary medicine and therapies · 2022Article
- Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition.Pharmaceutical biology · 2020Article
- Article
- Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats.Journal of ginseng research · 2020Article
- Anti-oxidative and anti-inflammatory activities of devil's club (Food science and biotechnology · 2017Article
- General and Genetic Toxicology of Enzyme-Treated Ginseng Extract: Toxicology of Ginseng Rh2.Journal of pharmacopuncture · 2016Article
- Commonly Used Dietary Supplements on Coagulation Function during Surgery.Medicines (Basel, Switzerland) · 2015Article
- 13-week subchronic toxicity study of a novel ginsenoside composition from ginseng leaves in rats.Laboratory animal research · 2014Article
- What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy lifestyle changes and/or Panax ginseng.Asian journal of andrology · 2012Review
- Chemical and pharmacological studies of Oplopanax horridus, a North American botanical.Journal of natural medicines · 2012Review
- Herbal medicines as adjuvants for cancer therapeutics.The American journal of Chinese medicine · 2012Article
- The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE).Indian journal of urology : IJU : journal of the Urological Society of India · 2012Article
- Possible Protective Role of Panax Ginseng on Cisplatin-Induced Hepatotoxicity in Adult Male Albino Rats (Biochemical and Histological Study).Journal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Ginseng is one of the most popular herbal supplements on the US market. Numerous reports of adverse effects from products containing ginseng have been filed with the US Food and Drug Administration (FDA) and the literature documents a "ginseng abuse syndrome" among regular users. However, the chronic toxic effects of ginseng are not well characterized. Because of its significant human exposure and the fact that little information on its toxicity is available, Panax ginseng was nominated by the US National Institutes of Health (NIH) to the US National Toxicology Program (NTP) to assess its carcinogenic potential. In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows that, under these experimental conditions, Panax ginseng is not toxic or tumorigenic.
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